莫西沙星与左氧氟沙星治疗尿路感染对治愈率、不良反应发生率的影响
Effect of moxifloxacin and levofloxacin on the cure rate of urinary tract infection and the incidence of adverse reactions
邵佳1
作者信息
- 1. 杭州市肿瘤医院 泌尿外科,浙江 杭州 310002
- 折叠
摘要
目的 探讨莫西沙星与左氧氟沙星治疗尿路感染对治愈率、不良反应发生率的影响.方法 选取2015年1月～2016年9月于杭州市肿瘤医院就诊的尿路感染患者92例,采用随机数字表法,分为A组与B组,每组各46例.A组患者给予莫西沙星治疗,B组患者给予左氧氟沙星治疗,对比2组患者的治疗效果.结果 A组患者的临床总有效率、临床治愈率显著高于B组,差异有统计学意义(P<0.05);2组患者的不良反应发生率、细菌清除率比较差异无统计学意义.A组患者不良反应发生率为10.87％,药物治疗成本为275.47元,成本-疗效比3.17;B组患者不良反应发生率为13.04％,药物治疗成本为45.50元,成本-疗效比0.59,2组患者的不良反应发生率比较差异无统计学意义;A组患者的药物成本、成本-效果比显著优于B组,差异有统计学意义( P <0.05).结论 莫西沙星治疗尿路感染的临床效果更显著,但左氧氟沙星治疗的药物成本更低.
Abstract
Objective To investigate the effect of moxifloxacin and levofloxacin on the treatment of urinary tract infection and the incidence of adverse reactions.Methods 92 cases of patients with urinary tract infection from January 2015 to September 2016 in Hangzhou cancer hospital were selected and randomly divided into group A and group B with 46 cases in each group.Group A were treated with moxifloxacin treatment,group B were treated with levofloxacin in the treatment,compared with the treatment of two groups of patients.Results The clinical effective rate and clinical cure rate of group A were significantly higher than those of group B,the difference was statistically significant(P<0.05),there was no significant difference in the incidence of adverse reactions and bacterial clearance between the two groups.The incidence of adverse reactions in group A was 10.87％,drug cost was 275.47 yuan,the cost effectiveness ratio of 3.17,the incidence of adverse reactions in group B was 13.04％,drug cost was 45.50 yuan,cost-effectiveness ratio of 0.59,there was no significant difference in the incidence of adverse reactions between the two groups; the cost of drug and cost-effectiveness of group A was significantly better than group B,the difference was statistically significant(P<0.05).Conclusion Moxifloxacin is more effective in the treatment of urinary tract infections,but levofloxacin has lower drug costs.
关键词
莫西沙星/左氧氟沙星/尿路感染/不良反应Key words
moxifloxacin/levofloxacin/urinary tract infection/adverse reaction引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据