摘要
目的 探讨右美托咪定对扁桃腺切除术患儿七氟醚复合麻醉苏醒期噪动的影响研究.方法 收集2011～2015年期间金华文荣医院行全麻下扁桃腺切除术患儿62 例,随机分为对照组和实验组,各31 例.2 组患儿均以静脉麻醉药丙泊酚2 mg/kg、舒芬太尼0.5 μg/kg、顺阿曲库铵0.2 mg/kg 静脉诱导,气管插管全身麻醉,术中以2％～4％七氟醚吸入及少量瑞芬太尼12 μg/(kg、h)、顺阿曲库铵0.1 mg/(kg、h)静脉泵注维持麻醉深度.实验组持续静脉泵入0.2 μg/(kg、h)右美托咪定至手术结束,对照组给予等量生理盐水静脉泵入.术毕比较2 组麻醉诱导前、麻醉诱导后、手术开始后5 min、手术结束时及收缩压、心率;麻醉拔管后5、10、15、20、25 min 躁动发生率.结果 与对照组相比,实验组麻醉诱导前收缩压、心率差异无统计学意义;麻醉诱导后、手术开始后5min、手术结束时患儿收缩压、心率较低( P <0.05);患儿苏醒时间、拔管时间、送离麻醉恢复室时间较短( P <0.05);儿麻醉拔管后5分钟、10分钟、15分钟、20分钟、25分钟躁动发生率较低( P <0.05).结论 右美托咪定在一定程度上可以预防扁桃腺切除术后七氟醚复合麻醉导致的苏醒期躁动发生.
Abstract
Objective To investigate the effects of dexmedetomidine on tonsillectomy in children with sevoflurane combined with anesthesia recovery period of restless.Methods A total of 62 patients with tonsillectomy under general anesthesia from 2011 to 2015 in our hospital werecollected and randomly divided into the control group and the experiment group with 31 cases in each.Two groups of children were treated by 7％sevoflurane inhalation anesthesia induction,supplemented by a small amount of intravenous anesthetics propofol 2 mg/kg,sufentanil 2 μg/kg,CIS atracurium 150 μg/kg intravenous injection.Patients in the experiment group were treated by dexmedetomidine 0.2 μg/(kg·h)continuous intravenous infusion until the end of the operation,patients in the control group were treated by normal saline intravenous infusion.Compared the systolic blood pressure and heart rate of the 2 groups of before anesthesia induction,after anesthesia induction,after operation 5min,the end of the operation ; occurred rate of restless at after anesthesia extubation 5minutes,10minutes,15minutes,20minutes,25minutes.Results Compared with the control group,the systolic blood pressure and heart rate of the experiment group without statistical significance before anesthesia induction; after anesthesia induction,after operation,5min,at the end of operation,the systolic blood pressure and heart rate were lower(P<0.05); children recovery time,extubation time,recovery time of delivery from the anesthesia room were shorter(P<0.05); occurred rate of restless were lower after anesthesia extubation 5minutes,10minutes,15minutes,20minutes,25minutes(P<0.05).Conclusion Dexmedetomidine can prevent tonsillectomy after sevoflurane anesthesia result in the recovery period of restless.
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维普
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