摘要
目的 评价氨甲环酸在髋部骨折围手术期的应用.方法 46例股骨粗隆间骨折患者随机分为对照组及试验组,各23例;所有患者接受PFNA内固定手术,术前10min,对照组给予0.9％氯化钠注射液100 mL,静脉滴注;试验组给予氨甲环酸注射液10 mg/kg,溶于100 mL0.9％氯化钠注射液,静脉滴注.比较2组患者手术前后血液红细胞比容(HCT)、血红蛋白(Hb)水平、失血量、输血量及术后并发症的发生率.结果 手术后,与对照组比较,试验组患者血液HCT、Hb水平较高(P<0.05).试验组的总失血量、隐性失血量、术中出血量、术后引流量及输血量较低( P <0.05).2组患者并发症的发生率差异无统计学意义.结论 氨甲环酸能够显著降低股骨粗隆间骨折患者围手术期的出血量及输血量,且不增加术后血栓并发症的发生率,具有较高安全性.
Abstract
Objective To evaluate the application of tranexamic acid in perioperative period of intertrochanter fracture of femur.Methods 46 cases of patients with intertrochanter fracture of femur were randomLy divided into the control group and treatment group,23 cases in each group.All patients underwent partial hip replacement,10min before operation,the control group was given 0.9％sodium chloride injection100mL,intravenous drip; the experimental group was treated with tranexamic acid injection 10mg/kg,soluble in 100mL 0.9％sodium chloride injection,intravenous drip;Before and after operation,compared between the two groups of patients with blood t hematocrit(HCT),hemoglobin(Hb)levels,volume of blood loss,volume of blood transfusion and incidence of postoperative complications.Results After operation,compared with the control group,the serum levels of HCT、Hb were higher in the experimental group(P<0.05).The total blood loss,hidden blood loss,intraoperative blood loss,postoperative drainage volume and blood transfusion volume were lower in the experimental group(P<0.05).There was no significant difference in the incidence of complications between the 2 groups.Conclusion The tranexamic acid can significantly reduce the volume of blood loss and volume of blood transfusion in perioperative period of patients with intertrochanter fracture of femur,and do not increase the incidence of postoperative complications of thrombosis,and have high security.
NETL
NSTL
维普
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