吡拉西坦联合高压氧对急性一氧化碳中毒患者心电图与乳酸清除率的影响
Effect of piracetam combine with hyperbaric oxygen in treatment of acute carbon monoxide poisoning patients with electrocardiogram and its effects on Lactate clearance
朱飞娟 1李琦 1袁靖 2熊丽荣 3王淼1
作者信息
- 1. 宁波市镇海区龙赛医院 急诊科,浙江 宁波 315200
- 2. 宁波市镇海区龙赛医院 ICU,浙江 宁波 315200
- 3. 宁波市医疗中心李惠利东部医院急诊科,浙江 宁波 315809
- 折叠
摘要
目的 研究吡拉西坦联合高压氧对急性一氧化碳中毒患者心电图与乳酸清除率的影响.方法 收集2011年2月～2016年2月我院接诊的60 例急性一氧化碳中毒患者.均符合急性一氧化碳中毒诊断标准,按抽签法分组.2 组均给予大量持续吸氧、降颅压、保护脑细胞、活血化瘀以及改善微循环等基础对症治疗.对照组在此基础上,加用高压氧治疗,每天1 次,共治疗10 次.实验组在基础治疗上,采用吡拉西坦联合高压氧治疗,高压氧方法同对照组,吡拉西坦氯化钠注射液进行静脉滴注,每次100 mL,每天2 次,共治疗10 d.观察2 组心电图异常,肌酸磷酸激酶同工酶(CK-MB)、肌钙蛋白(cTnl)、乳酸清除率,迟发性脑病发生率、病死率,治疗疗效.结果 2 组治疗前心电图异常率差异无统计学意义,治疗后,实验组异常率显著低于对照组[6.66(2/30)vs.33.33％(10/30)]( P <0.05);CK-MB、cTnl、治疗后6 h及治疗后24 h,乳酸清除率显著高于对照组[(15.80±2.03)％vs(10.26±2.01)％,(20.75±3.12)％vs.(13.07±2.56)％]( P <0.05);DEACMP率、病死率显著低于对照组[6.66％(2/30)vs.33.33％(10/30),3.33％(1/30)vs.30.00％(9/30)]( P <0.05);总有效率显著高于对照组[95.56％(28/30)vs.75.56％(22/30)]( P <0.05).结论 吡拉西坦联合高压氧对急性一氧化碳中毒能够取得满意的效果,可提高乳酸清除率,改善缺氧及心肌损伤,减少心电图异常.
Abstract
Objective To study effect of piracetam combine with hyperbaric oxygen in treatment of acute carbon monoxide poisoning patients with electrocardiogram and its effects on Lactate clearance.Methods 60 patients of acute carbon monoxide poisoning who received therapy from February 2011 to February 2016 in our hospital were selected as research objects.All accord with the diagnostic criteria of acute carbon monoxide poisoning.According to draw method,those patients were divided into the experimental group(n=30)and the control group(n=30).The two groups were given a large number of sustained oxygen,intracranial pressure,protect brain cells,promote blood circulation and improve microcirculation and other basic symptomatic treatment.The control group on the basis,was treated with hyperbaric oxygen,one times a day,a total of ten times.while the experimental group was treated with piracetam combine with hyperbaric oxygen,hyperbaric oxygen method with the control group,intravenous drip of Piracetam and Sodium Chloride Injection,each 100ml,two times a day,a total of treatment for ten days.Then abnormal ECG,creatine kinase isoenzymes(CK-MB),troponin(cTnl),lactate clearance,incidence of delayed encephalopathy,mortality,therapeutic effect of two groups were compared.Results ECG abnormal rate there was no difference between the two groups before treatment,after treatment,the abnormal rate of the experimental group was significantly lower than the control group [6.66(2/30)vs.33.33％(10/30)](P<0.05); CK-MB、cTnl、6h and 24h after treatment,Lactate clearance rate was significantly higher than control group[(15.80±2.03)％vs.(10.26±2.01)％,(20.75±3.12)％vs.(13.07±2.56)％](P<0.05);DEACMP rate and mortality was significantly lower than the control group[6.66％(2/30)vs.33.33％(10/30),3.33％(1/30)vs.30.00％(9/30)](P<0.05); The total effective rate was significantly higher than the control group[95.56％(28/30)vs.75.56％(22/30)](P<0.05).Conclusion Piracetam combine with hyperbaric oxygen is well for acute carbon monoxide poisoning,which can improve the clearance rate of lactic acid,improve hypoxia and myocardial injury,and reduce the abnormal ecg.
关键词
吡拉西坦/高压氧/急性一氧化碳中毒/心电图/乳酸清除率Key words
piracetam/hyperbaric oxygen/acute carbon monoxide poisoning/acute carbon monoxide poisoning/lactate clearance引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据