顺铂腹腔热灌注联合静脉化疗治疗中晚期胃癌的临床效果观察
Clinical observation of cisplatin intraperitoneal perfusion combined with intravenous chemotherapy in the treatment of advanced gastric cancer
黄志有 1马必东1
作者信息
- 1. 温州市中医院 肿瘤科,浙江 温州 325000
- 折叠
摘要
目的 探讨顺铂腹腔热灌注联合静脉化疗治疗中晚期胃癌临床疗效.方法 将82 例中晚期胃癌患者按照随机数字表法均分为2 组:观察组41 例给予顺铂腹腔热灌注联合静脉化疗,对照组41 例仅给予静脉化疗.观察近期疗效和不良反应发生情况.结果 观察组治疗总有效率为46.35％(19/41),对照组为26.83％(11/41),组间差异比较均有统计学意义( P <0.05);2组患者不良反应发生情况比较差异无统计学意义.观察组的IgA与IgG较对照组在治疗后提升的程度明显高,差异有统计学意义( P <0.05);观察组的IgM在治疗前后与对照组差异无统计学意义.结论 给予中晚期胃癌患者顺铂腹腔热灌注联合静脉化疗,可显著提高治疗效果,不增加不良反应.
Abstract
Objective To explore the clinical efficacy of cisplatin intraperitoneal perfusion combined with intravenous chemotherapy in the treatment of advanced gastric cancer.Methods 82 cases of patients with advanced gastric cancer were divided into two groups according to the random number table method: 41 cases of observation group were given cisplatin intraperitoneal perfusion combined with intravenous chemotherapy,41 cases in the control group received intravenous chemotherapy alone.To observe the short-term curative effect and adverse reaction.Results The total efficiency of treatment group were 46.35％(19/41)and the control group 26.83％(11/41),difference between the two groups was statistically significant(P< 0.05); the adverse reactions of the two groups of patients occurrence had no significant difference.Compared with the control group,the IgA and IgG in the observation group were significantly higher than that in the control group after treatment,the difference was significant(P<0.05); there was no significant difference between the IgM group and the control group before and after treatment.Conclusion Intraperitoneal perfusion combined with intravenous chemotherapy in patients with advanced gastric cancer can significantly improve the treatment effect,without increasing adverse reactions,it is worth popularizing.
关键词
局部进展期/胃癌/腹腔热灌注/静脉化疗Key words
local advanced stage/gastric cancer/intraperitoneal perfusion/intravenous chemotherapy引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据