红霉素与阿奇霉素对小儿肺炎支原体感染合并症的治疗效果分析
Analysis of azithromycin and erythromycin on contrast with central nervous system involvement in treatment of Mycoplasma pneumoniae infection in children
何惠玲 1邵利姣 2毛春发2
作者信息
- 1. 浙江省兰溪市妇幼保健院 儿科,浙江 兰溪 321100
- 2. 浙江省兰溪市人民医院 儿科,浙江 兰溪 321100
- 折叠
摘要
目的 对比阿奇霉素与红霉素对小儿肺炎支原体感染合并中枢神经系统受累的治疗效果.方法 选取2014年3月～2015年6月于浙江省兰溪市人民医院接受治疗的肺炎支原体感染合并中枢神经系统损伤的患儿为观察对象.根据其治疗方式分为治疗组(45 例)和对照组(50 例),对照组给予红霉素片,治疗组给予阿奇霉素.观察2 组患者的治疗效果,比较2 组患者治疗前后脑脊液炎症细胞因子水平和肺功能的差异.结果 治疗组治疗总有效率明显高于对照组,差异具有统计学意义(P<.0.05);治疗后,2组患者炎症因子水平均较降低,且治疗组显著低于对照组 (P<.0.05).结论 阿奇霉素与红霉素对小儿肺炎支原体感染合并中枢神经系统受累均有较好的治疗效果,且阿奇霉素效果更佳,具有较高的临床应用价值.
Abstract
Objective To compare the therapeutic effect of azithromycin and erythromycin in the treatment of children with Mycoplasma pneumoniae infection complicated with central nervous system involvement.Methods Mycoplasma pneumoniae infection in children with central nervous system damage treated in our hospital from March 2014 to June 2015 were selected as the observation object.According to the treatment method,it was divided into treatment group(45 cases)and control group(50 cases),the control group was given erythromycin tablets,the treatment group given azithromycin.To observe the therapeutic effect of two groups,compared the cerebrospinal fluid inflammatory cytokine levels and lung function of the two groups before and after treatment.Results The effective rate of treatment group was significantly higher than that of control group,and the difference was statistically significant(P<0.05); After treatment,the indexes of lung function in patients of the two groups were increased before treatment,and the treatment group increased more significantly(P<0.05); The level of hs-CRP,IL-6 and other inflammatory cytokine of the two groups of patients before treatment had no significantly difference,after treatment,the two groups of patients with the above indicators were lower than before treatment,and the treatment group decreased more significantly(P<0.05).Conclusion Azithromycin and erythromycin in children with Mycoplasma pneumoniae infection complicated with central nervous system involvement have better treatment effect,and the effect of azithromycin is better,has a high clinical value.
关键词
阿奇霉素/红霉素/肺炎/中枢神经/脑脊液/细胞因子Key words
azithromycin/erythromycin/pneumonia/central nervous system/cerebrospinal fluid/cytokine引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据