孟鲁司特钠咀嚼片对OSAHS患儿扁桃体及腺样体的影响
Effects of montelukast sodium chewable tablets on the tonsils and adenoids in children with OSAHS
单淑琴 1夏科君1
作者信息
- 1. 宁波市妇女儿童医院 儿科,浙江 宁波 315000
- 折叠
摘要
目的 探讨孟鲁司特钠咀嚼片治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患儿的疗效及对患者扁桃体及腺样体的影响.方法 选取2014年1月～2016年8月宁波市妇女儿童医院收治的OSAHS 患儿84 例,采用随机数字法将其分为对照组和观察组,每组各42 例.对照组患儿接受常规对症治疗,在此基础上,观察组患儿接受孟鲁司特钠咀嚼片治疗.比较2 组患儿的治疗总有效率,同时比较治疗前后的症状总评分、呼吸暂停低通气指数(AHI)、最低动脉血氧饱和度(LSaO2)及腺样体分级和扁桃体分度.结果 观察组的治疗总有效率(90.48％)明显高于对照组(69.04％,χ2 =5.97,P<.0.05);治疗后,观察组的症状总评分和AHI均明显低于对照组( P<.0.05),LSaO2明显高于对照组( P<.0.05),腺样体分级1级和2级比例明显高于对照组( χ 2=9.82, P<.0.05),扁桃体分度1度和2度比例差异无统计学意义.结论 孟鲁司特钠咀嚼片治疗OSAHS患儿的临床疗效显著,能有效缩小扁桃体和腺样体体积,对临床症状及睡眠治疗改善效果明显.
Abstract
Objective To study the montelukast sodium chewable tablets for the treatment of obstructive sleep apnea hypopnea syndrome(OSAHS)patients and treatment of tonsil and adenoid effect.Methods 84 cases of OSAHS patients in our hospital from January 2014 to August 2016 were randomly divided into the observation group and the control group,42 cases in each group.The control group was treated with conventional symptomatic treatment,on this basis,the patients in the observation group received montelukast sodium chewable tablets treatment,compared the two groups of the total efficiency,and compared before and after treatment of symptoms total score,apnea hypopneaIndex(AHI),the lowest arterial oxygen saturation(LSaO2),and adenoid and tonsil classification indexing.Results the total efficiency of observation group(90.48％)was significantly higher than the control group(69.04％,χ2=5.97,P<0.05); after treatment,the observation group of the total symptom score and AHI were significantly lower than the control group(P<0.05),LSaO2 was significantly higher than the control group(P<0.05),adenoid grade one and grade two were significantly higher than the control group(χ2=9.82,P<0.05),there was no significant difference between the one and two degrees of tonsil dividing ratio.Conclusion The clinical efficacy of montelukast sodium chewable tablets in the treatment of children with OSAHS is significant,can effectively reduce the volume of tonsil and adenoid body,and improve the clinical symptoms and sleep treatment significantly,which is worthy of clinical promotion.
关键词
孟鲁司特钠咀嚼片/阻塞性睡眠呼吸暂停低通气综合征/患儿/扁桃体/腺样体Key words
montelukast sodium chewable tablets/obstructive sleep apnea-hypopnea syndrome/children/tonsil/adenoid引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据