中国生化药物杂志2017,Issue(4) :333-335.DOI:10.3969/j.issn.1005-1678.2017.04.110

两种抗菌药物治疗小儿细菌性肠炎的效果及安全性分析

The effect and safety of two kinds of antimicrobial agents in the treatment of children with bacterial enteritis

张杰 王鋆
中国生化药物杂志2017,Issue(4) :333-335.DOI:10.3969/j.issn.1005-1678.2017.04.110

两种抗菌药物治疗小儿细菌性肠炎的效果及安全性分析

The effect and safety of two kinds of antimicrobial agents in the treatment of children with bacterial enteritis

张杰 1王鋆
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作者信息

  • 1. 浙江衢化医院 药剂科,浙江 衢化 324004
  • 折叠

摘要

目的 探讨小儿肠炎治疗中应用头孢他啶、头孢替安的临床效果差异.方法 选取2013年8月~2016年5月在本院接受诊治112 例肠炎患儿进行回顾性分析,根据治疗过程中应用的抗生素分为头孢他啶组60 例、头孢替安组52 例,头孢他啶组与头孢替安组患儿的补液、纠正电解质紊乱等基础治疗一致,对比临床效果差异.结果 治疗3 d、5 d 后,头孢他啶组的大便次数显著的低于头孢替安组( P< 0.05);头孢他啶组与头孢替安组患儿的血清CRP、PCT水平较治疗前均显著的降低( P< 0.05);治疗5 d后,头孢他啶组的显效率58.33%、有效率41.67%、无效率0%,头孢替安组的显效率为42.31%、有效率53.85%、无效率3.85%,头孢他啶组的治疗效果优于头孢替安组( P< 0.05).结论 小儿肠炎治疗中应用头孢他啶效果可靠,安全性高.

Abstract

Objective To investigate the clinical effect of the application of the clinical effect of the use of lamivudine and the safety in the treatment of infantile enteritis.Methods From August 2013 to May 2016 in our hospital for diagnosis and treatment of 112 cases of enteritis were retrospectively analyzed,according to the application in the treatment of antibiotics into ceftazidime group in 60 cases,cefotiam group 52 cases,two groups of children with rehydration,correct electrolyte disorders such as basic treatment,the difference of clinical effect comparison.Results After 3d treatment,ceftazidime group stool frequency was significantly lower than that of cefotiam group(P<0.05); ceftazidime group the duration of diarrhea,stool leukocyte recovery time were significantly lower than cefotiam group(P<0.05); three day,five day after treatment of serum CRP,PCT levels were ceftazidime group significantly lower than cefotiam group(P<0.05); the two groups of serum CRP and PCT levels before treatment were significantly decreased(P<0.05); After five days treatment,5D after treatment,ceftazidime group the effective rate of 58.33%,effective 41.67%,invalid rate 0%,cefotiam group the effective rate was 42.31%,effective 53.85%,invalid rate 3.85%,ceftazidime treatment group is better than that of cefotiam group(P<0.05).Conclusion In the treatment of infantile enteritis,the effect is reliable and the safety is high.

关键词

肠炎/头孢他啶/头孢替安

Key words

enteritis/lamivudine/safety

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出版年

2017
中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
被引量3
参考文献量10
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