替罗非班、阿司匹林和氯吡格雷三联抗血小板治疗对急性心肌梗死患者急诊经皮冠状动脉介入治疗后主要心脏不良事件发生率的影响
Effects of tirofiban, aspirin and clopidogrel on the incidence of major adverse cardiac events after percutaneous coronary intervention in patients with acute myocardial infarction
赵春勇 1魏广林 1高筱红 1金洪珍 1赵雪东 2王晓2
作者信息
- 1. 北京市平谷区医院 心血管内科,北京 101200
- 2. 首都医科大学附属北京安贞医院 心血管内科,北京 100029
- 折叠
摘要
目的 观察替罗非班、阿司匹林和氯吡格雷三联抗血小板在急性心肌梗死患者急诊经皮冠状动脉介入治疗效果及对主要心脏不良事件发生率的影响.方法 选取急性心肌梗死患者60 例,患者均采用经皮冠状动脉介入治疗,随机数字法分为对照组(n =30)和观察组(n =30).对照组采用氯吡格雷治疗,观察组采用替罗非班、阿司匹林和氯吡格雷三联抗血小板治疗,比较2 组临床疗效及对主要心脏不良事件发生率的影响.结果 2 组治疗前血小板聚集率及血小板计数比较差异无统计学意义.治疗后,观察组与对照组的血小板计数比较差异无统计学意义;观察组血小板聚集率、血小板对药物的反应情况MA-ADP 抑制率,低于对照组( P<.0.05)观察组的血小板对药物AA抑制率、ADP抑制率,高于对照组( P< 0.05);观察组治疗后主要心脏不良事件发生率为13.33％,对照组为33.33％,2组主要心脏不良事件发生率比较差异有统计学意义( P< 0.05).结论 急性心肌梗死患者急诊经皮冠状动脉介入治疗后采用替罗非班、阿司匹林和氯吡格雷三联抗血小板治疗效果理想,能降低主要心脏不良事件发生率.
Abstract
Objective To observe the effect of tirofiban,aspirin and Clopidogrel Hydrogen triple antiplatelet in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention and the effect on the incidence of major adverse cardiac events.Methods a total of 60 patients with acute myocardial infarction(AMI)in our hospital from January 2015 to-2016 in December were enrolled in this study.All patients were treated with percutaneous coronary intervention(PCI).The patients were randomly divided into control group(n=30)and observation group(n=30).The control group using clopidogrel hydrogen treatment,observation group were treated with tirofiban,aspirin and Clopidogrel Hydrogen triple antiplatelet therapy,the incidence and clinical effects of the two groups of major adverse cardiac events.Results the two groups before treatment,the platelet aggregation rate and platelet count had no statistically significant difference; no significant observation group after treatment compared 30d platelet count difference; observation group 30d after treatment,the platelet aggregation rate was lower than the control group(P<0.05); the observation group after the treatment of 30d MA-ADP on platelet drug reaction the inhibition rate is lower than the control group(P<0.05); the observation group after treatment of AA drugs 30d platelet inhibition rate,the inhibition rate of ADP,higher than that of the control group(P<0.05); the observation group after treatment,the incidence of major adverse cardiac events was 13.33％,33.33％in the control group,two groups of major adverse cardiac events was statistically significant the difference(P<0.05).Conclusion The patients with acute myocardial infarction undergoing primary percutaneous coronary intervention after treatment with tirofiban,aspirin and chlorine Pigre triple antiplatelet ideal treatment effect,can reduce the incidence of major adverse cardiac events,it is worthy of popularization and application.
关键词
替罗非班/阿司匹林/氯吡格雷/急性心肌梗死/经皮冠状动脉介入/心脏不良事件Key words
tirofiban/aspirin/clopidogrel/acute myocardial infarction/percutaneous coronary intervention/cardiac adverse events引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据