78例他汀类降脂药物与其他药物联用致不良反应分析
Analysis of adverse reactions induced by combination of statins and other drugs in 78 cases
杨绍鹏 1张健 1刘永莹1
作者信息
- 1. 天津市河西区康复医院 药剂科,天津 300200
- 折叠
摘要
目的 探讨分析他汀类药物与其他药物联用时所致的不良反应,为临床合理用药提供参考依据.方法 对天津市河西区康复医院2011年6月～2016年6月采用他汀类与其他药物联用导致出现不良反应的78例患者的临床资料进行回顾分析.结果 78例患者不良反应主要表现为肌肉毒性、肝毒性、消化系统不适、呼吸系统不适等,以肌肉毒性、肝毒性最为常见;其中横纹肌溶解症所占比例为20.51％,显著高于其它不良反应(P<0.05).他汀类药物中辛伐他汀和阿托伐他汀所致不良反应发生率分别为44.87％、28.21％,显著高于其它他汀类药物( P <0.05);且当他汀类药物与降压药、抗心肌类药物联用时不良反应发生率(30.77％)最高,与降脂类药物联用时不良反应发生率(20.51％)次之.结论 他汀类药物尤其是辛伐他汀和阿托伐他汀与降压、抗心肌、降脂等药物联用时不良反应的发生率相对较高,且不良反应以肝毒性、肌肉毒性为主要表现,因此在临床用药中应根据患者临床特征、药物类型制定规范合理的用药方案,最大限度减少不良反应的发生.
Abstract
Objective To investigate the adverse reactions induced by statins when combined with other drugs and its influencing factors,so as to provide reference for clinical rational drug use.Methods The clinical data of 78 patients with adverse reactions caused by statins combined with other drugs in our hospital from June 2011 to June 2016 were reviewed and analyzed.Results The adverse reactions of the 78 cases of patients were manifested as muscle toxicity,liver toxicity,digestive discomfort,respiratory discomfort,et al; Inwhich muscle toxicity and liver toxicity were the most common adverse reactions.The incidence rate of rhabdomyolysis was 20.51％,which was significantly higher than that of the other adverse reactions(P<0.05).The incidence rates of adverse reactions induced by simvastatin and atorvastatin were 44.87％and 28.21％,significantly higher than other statins(P<0.05).The incidence of side effects was the highest(30.77％)when the statins combined with antihypertensive drugs and anti myocardial drugs,and the incidence of adverse reactions was 20.51％when combined with lipid-lowering drugs.Conclusion The adverse reaction rate is relatively high when statins,especially simvastatin and atorvastatin combined with antihypertensive,anti-myocardial and lipid-lowering drugs,and the adverse reactions to liver toxicity and muscle toxicity are the main performance.Therefore a standardized and rational medication regimen should be made based on the clinical characteristics of patients and the type of drug in the clinical use of statins,in order to reduce the incidence of adverse reactions to the maximum limit.
关键词
他汀类药物/联合用药/不良反应/临床分析Key words
statins/combination therapy/adverse reactions/clinical analysis引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据