摘要
目的 探讨降钙素原(PCT)对小儿重症感染的诊断价值.方法 回顾性分析2013年12月～2016年2月在江山市妇幼保健院接受治疗的感染性疾病患儿的临床资料,根据其感染程度分为局部感染组和重症感染组,同时选取50例非感染性疾病患儿的临床资料作为对照组.观察3组患儿血清PCT、细胞因子水平的差别,同时根据患儿预后将重症感染组患儿分为好转组和恶化组,观察好转组和恶化组重症感染患儿血清PCT、炎症细胞因子水平的差异,分析重症患儿PCT水平与血清炎症细胞因子水平的相关性.结果 3组血清PCT、IL-18、IL-6和hs-CRP水平存在显著差别,由高到低分别为:重症感染组、局部感染组和对照组;恶化组PCT、IL-18、IL-6和hs-CRP水平均高于好转组(t=-10.099、-8.949、-10.827、-2.088,P<0.05);重症感染患儿PCT水平与IL-18、IL-6和hs-CRP水平均正相关( r =0.385、0.412、0.408, P =0.012、0.008、0.017).结论 PCT对重症感染患儿有较好的诊断价值,且与患儿的炎症细胞因子水平和预后密切相关.
Abstract
Objective To investigate the value of PCT in the diagnosis of severe infection in children.Methods The clinical data of patients with infectious diseases treated in our hospital from December 2013 to February 2016 were retrospectively analyzed.According to the degree of infection,the patients were divided into local infection group and severe infection group,At the same time,the clinical data of 50 children with non infectious diseases were selected as control group.The differences of serum PCT and cytokine levels were observed between the three groups,at the same time,according to the prognosis of patients with severe infection group were divided into improvement group and deterioration group,The differences of serum PCT and inflammatory cytokines levels in the patients with severe infection in the improvement group and the worsening group,Analysis of the correlation between PCT levels and serum inflammatory cytokines levels in children with severe.Results There were significant differences in the levels of PCT,IL-18,IL-6 and hs-CRP between the three groups,which were from high to low: severe infection group,local infection group and control group; Deterioration of PCT,IL-18,IL-6,hs-CRP and levels were higher than the improvement group(t=-10.099,-8.949,-10.827,-2.088,P<0.05); The level of PCT were positively correlated with IL-18,IL-6 and hs-CRP levels in children with severe infection(r=0.385,0.412,0.408,P=0.012,0.008,0.017).Conclusion PCT has a good diagnostic value in children with severe infection,and it is closely related with the level of inflammatory cytokines in children with severe infection.
NETL
NSTL
维普
万方数据