酪酸梭菌活菌散治疗小儿消化不良性腹泻的效果观察
Observation on the effect of clostridium butyricum powder in treating infantile indigestion diarrhea
刘英 1庞淑慧 1冯芹1
作者信息
- 1. 山东大学第二医院药学部,山东济南250033
- 折叠
摘要
目的 探讨酪酸梭菌活菌散治疗小儿消化不良性腹泻的临床效果.方法 选取2013年2月~2015年10月在山东大学第二医院儿科接受治疗的76例消化不良性腹泻患儿作为研究对象,采用随机数字表法分为试验组和对照组各38例,2组患儿均给予保儿宁颗粒,联合组同时加用酪酸梭菌活菌散治疗,3d为1个疗程,连续治疗2个疗程.结果 治疗前,试验组和对照组的各项临床症状积分差异无统计学意义,治疗后,试验组的食欲不振、腹痛、腹泻、腹胀及大便性状积分均低于对照组,差异具有统计学意义(P<0.05);治疗前,试验组和对照组的血清胃动素、胃泌素、生长抑素水平差异无统计学意义,治疗后,试验组的血清胃动素、胃泌素水平均低于对照组,血清生长抑素水平高于对照组,差异具有统计学意义(P<0.05);治疗后,试验组的总有效率92.11%高于对照组73.68%,差异具有统计学意义(P<0.05).结论 酪酸梭菌活菌散结合保儿宁颗粒治疗小儿消化不良性腹泻效果较好,值得临床推广应用.
Abstract
Objective To investigate the clinical effect of Clostridium butyricum powder in treating infantile indigestion diarrhea.MethodsFrom February 2013 to October 2015 in our hospital 76 cases of pediatric indigestion diarrhea as the research object, randomly divided into experimental group and control group with 38 cases in each group, two groups were given Bao,er ning granule, combined group plus live bacteria powder for the treatment of Clostridium butyricum, three days for a course of treatment, continuous treatment of two courses.ResultsBefore treatment, there was no significant difference in clinical symptom scores between the experimental group and the control group,after treatment,the scores of loss of appetite, abdominal pain, diarrhea, abdominal distension and stool of the experimental group were lower than those of the control group, the difference was statistically significant (P<0.05);Before treatment, there was no significant difference in serum motilin, gastrin and somatostatin levels between the experimental group and the control group.After treatment, the levels of serum motilin and gastrin in the experimental group were lower than those in the control group, and the level of serum somatostatin was higher than that of the control group, the difference was statistically significant (P<0.05);After treatment, the total effective rate of experimental group was 92.11% higher than that of control group 73.68%, the difference was statistically significant (P<0.05).ConclusionClostridium butyricum powder with Bao,er ning granule in the treatment of infantile dyspeptic diarrhea effect is good, worthy of clinical application.
关键词
酪酸梭菌活菌散/消化不良/腹泻Key words
clostridium butyricum powder/dyspepsia/diarrhea引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据