首页|益肾安胎方联合黄体酮治疗复发性流产的疗效研究

益肾安胎方联合黄体酮治疗复发性流产的疗效研究

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目的 分析和研究中药益肾安胎方对于复发性流产中IL-4、 IFN-γ细胞因子的作用机制.方法 选取2013年1月~2015年12月符合入选条件的复发性流产患者60例,根据随机数字表法,将其随机分为中医组、西医组、中西医结合组,中医组予以中药益肾安胎方,西医组予以黄体酮针肌注,中西医结合组予以黄体酮针联合中药.疗程均为15d,观察治疗前后患者的妊娠结局以及IL-4、 IFN-γ水平变化.结果 3组治疗前的IL-4、IFN-γ差异均无统计学意义.治疗后,与中西医结合组相比,西医组、中医组的IL-4、IFN-γ分别呈上升、下降趋势,差异有统计学意义(P<0.05).治疗后,与中医组相比西医组的IL-4、IFN-γ也分别呈上升、下降趋势,差异有统计学意义(P<0.05).中西医结合组获得较高的临床治愈率.结论 中西医结合组对于改善复发性流产的妊娠结局疗效确切,可能与明显改善IL-4、IFN-γ的表达相关,有助于提高IL-4,降低IFN-γ的表达,改善妊娠结局.
Study on curative effect of Yishen recipe combined with progesterone in the treatment of recurrent spontaneous abortion
Objective To analyze and research the Chinese medicine of tonifying kidney recipe on the mechanism of recurrent spontaneous abortion IL-4, IFN-gamma cytokine.Methods60 patients in accordance with the inclusion criteria with recurrent miscarriage from January 2013 to December 2015 were selected, according to the random number table method, the patients were randomly divided into Chinese medicine group, Western medicine group,Combine traditional Chinese and western medicine group, Chinese medicine group treated with traditional Chinese medicine of tonifying kidney recipe, Western Medicine group were given intramuscular injection of progesterone injection,combining traditional Chinese and Western medicine group was treated with acupuncture combined with progesterone Chinese medicine.The course of treatment was 15 days, before and after treatment in patients with pregnancy outcome and IL-4, IFN-gamma levels.ResultsThere was no significant difference between the three groups before treatment with IL-4 and IFN-.After treatment,compared with the traditional Chinese and Western medicine group, western medicine group, Chinese medicine group of IL-4, IFN-, respectively, showed a rise and fall, the difference was statistically significant(P<0.05).After treatment, compared with the traditional Chinese medicine group, the IL-4 and IFN-of the western medicine group were increased and decreased, respectively, and the difference was statistically significant (P<0.05).Combination of traditional Chinese and Western medicine to obtain a higher clinical cure rate.ConclusionThe combination of TCM and Western medicine for improving the efficacy of pregnancy outcome of recurrent spontaneous abortion and exact expression may obviously improve the IL-4 and IFN-gamma, help to improve the IL-4, reduce the expression of IFN-gamma, improve the outcome of pregnancy.

Yishen reciperecurrent spontaneous abortionIL-4IFN-γ

王美霞、胡慧娟、谢一红、陈浩波

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温州市中西医结合医院中医妇科,浙江温州325002

益肾安胎方 复发性流产 IL-4 IFN-γ

温州市科技局课题

2013S0195

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(5)
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