首页|通络化瘀汤联合针刺对大动脉闭塞性脑梗死患者脑白质损伤的临床效果

通络化瘀汤联合针刺对大动脉闭塞性脑梗死患者脑白质损伤的临床效果

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观察通络化瘀汤联合针刺对大动脉闭塞性脑梗死患者脑白质损伤的疗效.方法 选取2013年4月~2015年1月奉化锦元堂中医门诊部针灸科收治的大动脉闭塞性脑梗死伴脑白质损伤患者76例为研究对象,采用随机数表法分为观察组和对照组各38例,对照组给予常规西药治疗,观察组在对照组基础上加服中药通络化瘀汤,并配合针刺治疗,2组均治疗2个月,比较其治疗有效率,分析2组治疗前后血小板最大聚集率(MAR)、血小板活化颗粒膜糖蛋白62P(CD62P)水平,同时采用美国国立卫生院神经功能缺损评分表(NIHSS)、蒙特利尔认知评估量表(MOCA)、Barthel指数(BI)分析其预后情况,并观察不良反应.结果 观察组治疗有效率94.74%明显高于对照组78.95%(P<0.05);治疗后观察组CD62P(21.87±1.55)%、MAR(35.23±1.62)%、NIHSS评分(10.27±0.78)分较对照组低(P<0.05),观察组MOCA评分(25.04±1.11)分、BI指数(88.15±1.20)分,与对照组比较明显较高(P<0.05);2组不良反应发生率13.16%、7.89%比较无统计学意义.结论 针刺联合中药通络化瘀汤可有效保护大动脉闭塞性脑梗死患者脑白质,改善其血小板CD62P、MAR及神经功能、认知功能,提高生活质量,且不良反应轻,值得在临床推广应用.
Clinical effect of Tongluo huayu decoction combined with acupuncture on cerebral white injury in patients with arterial cerebral infarction
Objective To observe the clinical effect of acupuncture combined with traditional Chinese medicine Tongluo huayu decoction on white matter damage in patients with occlusive cerebral infarction.MethodsA total of 76 patients with cerebral infarction with cerebral hemorrhage were enrolled in this study from April 2013 to January 2015.The random number table was divided into observation group and control group (38 cases).The control group was given routine western medicine treatment, the observation group on the basis of the control group plus traditional Chinese medicine tongluo huayu decoction, and with acupuncture treatment, the two groups were treated for 2 months, compare the effectiveness of treatment, analysis of the two groups before and after treatment platelet aggregation rate MAR (CDCA) and platelet-activated granule membrane glycoprotein 62P (CD62P), and the prognosis was analyzed by NIHSS, Montreal Metabolic Assessment Scale (MoCA) and Barthel Index (BI) Observe adverse reactions.ResultsThe effective rate of the observation group was 94.74% higher than that of the control group (78.95%, P< 0.05).After treatment, the expression of CD62P (21.87±1.55)%, MAR (35.23±1.62)% and NIHSS score (10.27±0.78) (P< 0.05).The incidence of adverse events was 13.16% in the observation group (25.04±1.11) and the BI index (88.15±1.20) were significantly higher than those in the control group (P< 0.05);There was no significant difference in the prevalence of adverse effects between 13.16% and 7.89%.ConclusionAcupuncture combined with traditional Chinese medicine Tongluo huayu decoction can effectively protect the white matter of patients with massive arterial occlusive cerebral infarction, improve its platelet CD62P, MAR and neurological function, cognitive function, improve the quality of life, and mild adverse reactions, it is worth in the clinical promotion application.

Tongluo huayu decoctionacupuncturegreat arterial occlusive cerebral infarctionwhite matter

许小侔、宋秋云、鲍含敏

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奉化锦元堂中医门诊部针灸科,浙江宁波315500

奉化区中医院神经内科,浙江宁波315500

通络化瘀汤 针刺 大动脉闭塞性脑梗死 脑白质

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(5)
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