首页|化肝解毒汤联合复方甘草酸苷对慢性乙肝患者血清肝炎相关因子水平的影响

化肝解毒汤联合复方甘草酸苷对慢性乙肝患者血清肝炎相关因子水平的影响

扫码查看
目的 探讨中药化肝解毒汤联合复方甘草酸苷对慢性乙肝患者血清肝炎相关因子水平的影响.方法 选取2014年9月~2015年8月温州医科大学附属第一医院消化内科收治的慢性乙肝患者86例为研究对象,采用随机数表法分为观察组和对照组各43例,对照组给予复方甘草酸苷等常规西药治疗,观察组在此基础上加服中药化肝解毒汤,对比两组治疗有效率及治疗前后中医症候积分,比较其丙氨酸氨基转移酶(ALT)、血清总胆红素(TBil)、白蛋白(Alb)评价肝功能,对比两组透明质酸酶(HA)、层粘连蛋白(LN)、Ⅳ型胶原(Ⅳ-C)、Ⅲ型前胶原(PCⅢ)分析肝纤维化功能,并观察不良反应.结果 观察组治疗有效率93.02%明显高于对照组76.74%(P<0.05);观察组治疗后胸肋不适、情绪抑郁、胃脘胀满、倦怠乏力、口淡乏味、便溏不爽、乳房胀痛、舌质淡红等中医症候积分与总积分低于对照组(P<0.05);治疗后观察组ALT(35.28±1.35)U/L、HA(165.25±1.44)mg/L、LN(123.17±1.96)μg/L、Ⅳ-C(110.24±1.94)μg/L、PCⅢ(125.36±1.35)μg/L较对照组下降,而其血清TBil(30.44±1.59)μmol/L、Alb(48.32±1.33)g/L高于对照组(P<0.05);两组不良反应发生率11.63%、6.98%比较差异无统计学意义.结论 中药化肝解毒汤联合复方甘草酸苷可有效治疗慢性乙肝,改善其血清肝炎相关因子水平,且不良反应轻,值得在临床推广应用.
Effect of liver detoxification soup combined with compound glycyrrhizin on hepatitis related factors in patients with chronic hepatitis B
Objective To investigate the effect of liver detoxification soup combined with compound glycyrrhizin on hepatitis-related factors in patients with chronic hepatitis B.MethodsFrom April 2014 to August 2015, 86 patients with chronic hepatitis B were enrolled in this study.Random number table was divided into observation group and control group (43 cases).The control group was given routine glycyrrhizin and other conventional (ALT), serum total bilirubin (TBil), serum albumin transferase (ALT) and serum total bilirubin (TBil) were measured before and after treatment.(HA), laminin (LN), type Ⅳ collagen (Ⅳ-C) and type Ⅲ procollagen (PCⅢ) were used to analyze the effect of hepatic fibrosis, And observe adverse reactions.ResultsThe effective rate of the observation group was 93.02% higher than that of the control group (76.74%, P<0.05).After treatment, the patients were treated with chest discomfort, emotional depression, epigastric fullness, fatigue, ALT (35.28±1.35) U/L, HA (165.25±1.44) mg/L, and the treatment group (P<0.05).After treatment, the levels of TBil (30.34±1.59)μmol/L, Alb (48.32±1.33)g/L, and the level of serum was significantly higher than that of the control group (P<0.01).The incidence of adverse reactions was 11.63% and 6.98% in the two groups.ConclusionTraditional Chinese medicine hepatectomy decoction combined with compound glycyrrhizin can effectively treat chronic hepatitis B and improve the level of serum hepatitis-related factors, and the adverse reaction is light, it is worthy of clinical application.

liver detoxification soupcompound glycyrrhizinchronic hepatitis BHepatitis-related factor

吴芳、董乐妹、陈小微、吴伟

展开 >

温州医科大学附属第一医院消化内科,浙江温州325000

化肝解毒汤 复方甘草酸苷 慢性乙肝 肝炎相关因子

温州医科大学附属第一医院青年英才计划资助项目

qnyc071

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(5)
  • 7
  • 10