目的 研究痰热清注射液对重型颅脑损伤患者肺部感染病原菌及炎症因子的影响.方法 收集2012年4月~2015年4月宁波市第九医院接诊的80例重型颅脑损伤患者,均出现肺部哮鸣音、喘息、呼吸急促、发热等临床症状.按抽签法分组,分为实验组40例和对照组40例,2组均进行药物敏感试验给予相应的抗菌药物,治疗疗程为2周.对照组采用常规治疗,实验组在对照组基础上,采用痰热清注射液治疗.观察2组治疗疗效,体温,肺部啰音消失时间、咳嗽咳痰消失时间,感染病原菌阳性率,中性粒细胞、白细胞计数、降钙素原、超敏C反应蛋白恢复时间,白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平.结果 治疗后,实验组总有效率显著高于对照组[95.00%(38/40) vs 70.00%(28/40)] (P<0.05);体温、肺部啰音消失时间、咳嗽咳痰消失时间显著短于对照组[(4.90±1.02)d vs (9.06±2.16)d,(6.02±1.21)d vs (10.85±2.37)d,(5.79±1.03)d vs (9.65±1.68)d](P<0.05);感染病原菌阳性率显著低于对照组[5.00%(2/40) vs 47.50%(19/40)](P<0.05);中性粒细胞、白细胞计数、降钙素原、超敏C反应蛋白恢复时间显著短于对照组[(6.10±1.20)d vs.(9.06±1.68)d,(4.72±0.97)d vs.(7.34±1.23)d,(7.67±1.26)d vs.(11.93±1.57)d,(7.21±1.02)d vs (11.29±1.73)d](P<0.05);IL-6、TNF-α水平显著低于对照组[(85.91±9.03)ng/L vs.(102.08±10.42)ng/L,(17.38±1.01)ng/L vs.(24.05±1.37)ng/L](P<0.05).结论 痰热清注射液治疗重型颅脑损伤患者疗效显著,能够改善患者的临床症状,保护脑组织,显著降低肺部感染病原菌,调节炎症因子的表达.
Curative efficacy of tanreqing injection in treatment of Severe craniocerebral injury in patients with Pulmonary infection pathogen and its effects on Inflammatory factor
Objective To study curative efficacy of tanreqing injection in treatment of severe craniocerebral injury in patients with pulmonary infection pathogen and its effects on Inflammatory factor.Methods80 patients of severe craniocerebral injury who received therapy from April 2012 to April 2015 in our hospital were selected as research objects.There were pulmonary wheezing, wheezing, shortness of breath, fever and other clinical symptoms.According to draw method,those patients were divided into the experimental group (n=40) and the control group (n=40).Two groups were given drug sensitivity test to give the corresponding antibacterial drugs, treatment for 2 weeks, The control group was treated with routine treatment, while the experimental group was on the basis of the control group, treated with tanreqing injection, every time 30ml, add 5% glucose Injection 250ml after mixing, intravenous infusion, 1 times a day.Then the curative effect, body temperature, pulmonary rales disappeared, cough disappeared time, the infection rate of pathogenic bacteria, neutrophils, white blood cell count, procalcitonin, high sensitivity C reactive protein recovery time, interleukin-6(IL-6), tumor necrosis factor-α(TNF-α) level of two groups were compared.ResultsAfter treatment, the total effective rate of the experimental group was significantly higher than the control group[95.00%(38/40) vs 70.00%(28/40)] (P<0.05);Body temperature, pulmonary rales disappeared, cough and expectoration disappeared time was significantly shorter than the control group[(4.90±1.02)d vs (9.06±2.16)d,(6.02±1.21)d vs (10.85±2.37)d,(5.79±1.03)d vs (9.65±1.68)d](P<0.05);The positive rate of pathogenic bacteria was significantly lower than the control group[5.00%(2/40)vs 47.50%(19/40)](P<0.05);The recovery time of neutrophil, white blood cell count, procalcitonin and high sensitive C reactive protein was significantly shorter than the control group[(6.10±1.20)d vs (9.06±1.68)d,(4.72±0.97)d vs (7.34±1.23)d,(7.67±1.26)d vs (11.93±1.57)d,(7.21±1.02)d vs (11.29±1.73)d](P<0.05);IL-6、TNF-α level was significantly lower than the control group[(85.91±9.03)ng/L vs (102.08±10.42)ng/L,(17.38±1.01)ng/L vs (24.05±1.37)ng/L] (P<0.05).ConclusionTanreqing injection is well for severe craniocerebral injury,which can improve the clinical symptoms, protect the brain tissue, significantly reduce the pathogenic bacteria of pulmonary infection, and regulate the expression of inflammatory factors.
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