首页|行气活血颗粒联合低分子肝素预防下肢骨折术后深静脉血栓的临床效果观察

行气活血颗粒联合低分子肝素预防下肢骨折术后深静脉血栓的临床效果观察

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目的 观察研究行气活血颗粒联合低分子肝素预防下肢骨折术后深静脉血栓的临床疗效.方法 选取浙江省金华市东阳市人民医院骨科2014年2月~2015年2月收治疗下肢骨折术的患者共60例,按随机数字表法分为观察组和对照组各30例,对照组给予低分子肝素预防下肢骨折术后深静脉血栓治疗,观察组给予行气活血颗粒治疗,随访并记录2组患者相关指标变化情况.结果 (观察组患者治疗后毛细管血浆黏度、红细胞压积、红细胞聚集指数值分别为(1.52±0.11、41.78±2.30%、2.19±0.16分),均优于对照组(1.42±0.14、39.02±2.07%、2.01±0.23分),且差异有显著性(P<0.05).(观察组患者治疗后血小板为(189.4±37.0)×10.9/L,优于对照组(259.3±40.1)×10.9/L,且差异有显著性(P<0.05).(观察组治疗后PT及APTT值分别为(16.0±2.79、36.78±4.59)s,优于对照组(13.96±2.94、33.14±4.47)s,且差异有显著性(P<0.05).观察组治疗后用药后不良反应发生比例为6.67%,优于对照组30.00%,且差异有显著性(P<0.05).结论 行气活血颗粒联合低分子肝素预防下肢骨折术后深静脉血栓的临床治疗效果确切,无明显副反应,值得临床进一步研究和应用.
The clinical effect of Xingqihuoxue granule combined with low molecular weight heparin to prevent deep vein thrombosis after operation of lower limb fracture surgery
Objective To observe The clinical effect of Xingqihuoxue granule combined with low molecular weight heparin to prevent deep vein thrombosis after operation of lower limb fracture surgery.Methods60 patients from February 2014 to February 2015, were randomly divided into observation group 30 cases and the control group 30 cases.The control group received low molecular weight heparin, the observation group received Xingqihuoxue granule.Two groups of patients were followed up and recorded the changes related indicators.ResultsThe level of capillary plasma viscosity, hematocrit, red blood cell and aggregation index values of observation group patients after treatment were (1.52±0.11,41.78±2.30%, 2.19±0.16 points), than the control group (1.42±0.14,39.02±2.07%, 2.01±0.23 points), and the difference was significant (P<0.05).The level of platelets of observation group patients was (189.4±37.0)×10.9 / L, than the control group (259.3±40.1) × 10.9/L, and the difference was statistically significant (P<0.05).The level of PT and APTT of the observation group after treatment were (16.0±2.79,36.78±4.59) s, than the control group (13.96±2.94,33.14±4.47) s, and the difference was statistically significant (P<0.05).The adverse reaction ratio of observation group after treatment was 6.67%, lower than the control group 30.00%, and the difference was statistically significant (P<0.05).ConclusionsThe clinical treatment of Xingqihuoxue granule combined with low molecular weight heparin was better than low molecular weight heparin alone, and the side effects was lower.It is worthy of further research and application.

Xingqihuoxue granulelow molecular weight heparinlower limb fracture surgerydeep vein thrombosis

张正良、吕晓强、徐杰、张永进

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浙江省金华市东阳市人民医院骨科,浙江金华322100

行气活血颗粒 低分子肝素 下肢骨折术 深静脉血栓

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(5)
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