参丹散结胶囊对晚期非小细胞肺癌患者化疗疗效及免疫的影响分析
Influences of Shendan Sanjie capsule on chemotherapy effect and immune index to patients with advanced non-small cell lung cancer
汪浙炯 1卜兴胜 2谈潘莉 1孙菊琴1
作者信息
- 1. 浙江省中医院检验科,浙江杭州321017
- 2. 浙江大学医学院附属妇产科医院检验科,浙江杭州310006
- 折叠
摘要
目的 观察参丹散结胶囊对晚期非小细胞肺癌患者化疗疗效及免疫的影响.方法 研究资料为2014年1月~2016年5月期间,浙江省中医院收治的76例晚期非小细胞肺癌患者,随机按照入院顺序编号,奇数为对照组(38例),该组进行常规化疗治疗,偶数为观察组(38例),于化疗期间加用参丹散结胶囊.分析2组患者化疗前后的疗效差异以及免疫差异.结果 ①化疗后对照组CD4+下降、CD8+升高、CD4+/CD8+下降,和化疗前比,差异均有统计学意义(P<0.05);观察组CD4+、CD8+、CD4+/CD8+和化疗前相比,差异无统计学意义.化疗后观察组CD4+、CD8+、CD4+/CD8+均优于对照组(均P<0.05).②化疗后,对照组RR比例为36.84%,低于观察组57.89%(P<0.05).③化疗后2组中部分患者出现毒副作用,但观察组发生毒副反应比例较对照组低(P<0.05).结论 对于非小细胞肺癌患者,参丹散结胶囊可调节患者在化疗期间的免疫力,控制化疗引起的毒副作用.
Abstract
Objective To observe the influences of Shendan Sanjie capsule on chemotherapy effect and immune index to patients with advanced non-small cell lung cancer.MethodsDividing 76 patients with advanced non-small cell lung cancer from department of oncology from January 2014 to May 2016,each with 38 cases.The control group recei-ved western chemotherapy,observation group received western chemotherapy with Shendan Sanjie capsule.The differences of related indicators were compared.Results①After chem-otherapy,in the control group, CD4+decreased,CD8+ increased and CD4+/CD8+ decreased,and before chemotherapy, the difference was significant(P<0.05).In observation group,there was no significant difference in CD4+, CD8+, CD4+ / CD8+ levels.The above indicators of observation group were better than that of control group.②After chemotherapy,RR(CR+PR)rate of observation group were 57.89%, higher than the control group with 36.84%(P<0.05).③During chemotherapy,toxic side effect ratio of observation group was lower than that of the control group(P<0.05).ConclusionComparing Shen Dan Sanjie capsule can adjust patient immunity and reduce side effects of chemotherapy during chemotherapy.
关键词
参丹散结胶囊/非小细胞肺癌/化疗/免疫Key words
Shendan Sanjie capsule/non-small cell lung cancer/chemotherapy/immune引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据