首页|四逆散联合灌肠保守治疗慢性非特异性溃疡性结肠炎的临床研究

四逆散联合灌肠保守治疗慢性非特异性溃疡性结肠炎的临床研究

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目的 分析四逆散联合灌肠保守治疗慢性非特异性溃疡性结肠炎的临床效果.方法 随机将2015年1月~2016年10月本院收治的132例慢性非特异性溃疡性结肠炎患者分成2组,每组66例.对照组给予灌肠方案,观察组在灌肠基础上加用四逆散,分析四逆散对该疾病的作用.结果 ①总有效率:观察组93.94%,对照组75.76%(P<0.05).②治疗后,观察组血清CRP、IL-8和TNF-ɑ水平分别为(14.92±3.04)mg/L、(0.52±0.05)μg/L、(18.65±3.18)ng/L,均低于对照组(23.04±3.31)mg/L、(0.75±0.08)μg/L、(25.59±3.62)ng/L(均P<0.05).③治疗后,观察组血沉(ESR)和血小板(PLT)分别为(11.16±2.27)mm/h、(220.6±15.8)×10.9/L,均低于对照组(15.93±2.58)mm/h、(258.3±18.9)×10.9/L(均P<0.05).④不良反应率:观察组为15.15%,对照组21.22%,差异无统计学意义.⑤复发率:观察组为23.81%,低于对照组39.06%(P<0.05).结论 四逆散可提高慢性非特异性溃疡性结肠炎疗效,且用药安全.
Clinical effects of Sini powder combing with enema in treatment of chronic nonspecific ulcerative colitis
Objective To research clinical effects of Sini powder combing with enema in treatment of chronic nonspecific ulcerative colitis.Methods132 patients with chronic nonspecific ulcerative colitis treated in our hospital from January 2015 to October 2016 were randomly divided into two groups,with 66 cases in each group.The control group was treated with enema,and observation group was treated with Sini powder combing with enema to analyse effect of Sini powder.Results①The total effective rate was 93.94% in the observation group,higher than control group 75.76%(P<0.05).②After treatment,serum CRP,IL-8 and TNF-ɑ level of observation group were (14.92±3.04)mg/L、(0.52±0.05)μg/L、(18.65±3.18)ng/L,lower than control group(23.04±3.31)mg/L、(0.75±0.08)μg/L、(25.59±3.62)ng/L(all P<0.05).③ ESR and PLT level of observation group were(11.16±2.27)mm/h、(220.6±15.8)×10.9/L,lower than control group(15.93±2.58)mm/h、(258.3±18.9)×10.9/L(all P<0.05).④The adverse reaction rate was 15.15% in the observation group,and 21.22% in the control group, the difference was not statistically significant.⑤ The recurrence rate was 23.81% in the observation group,lower than control group 39.06%(P<0.05).ConclusionSini powder can improve the effect in treatment of chronic nonspecific ulcerative colitis and has higher security.

Sini powderenemachronic nonspecific ulcerative colitisinflammationrecurrence rate

朱康明、陈诚豪

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兰溪市人民医院,浙江兰溪321100

浙江省同德医院肛肠科,浙江杭州310000

四逆散 灌肠 慢性非特异性溃疡性结肠炎 炎症 复发率

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(5)
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