女性抗精子免疫性不孕与慢性生殖道炎症的相关性研究
The relationship between female anti-sperm immune infertility and chronic inflammation in female reproductive tract
袁浩1
作者信息
- 1. 浙江省杭州市桐庐县第一人民医院妇产科,浙江杭州311500
- 折叠
摘要
探讨女性抗精子免疫性不孕与慢性生殖道炎症相关性的临床研究.方法 选取80例抗精子抗体免疫性不孕症患者,随进分为研究组和对照组,研究组给予地塞米松+维生素E+维生素C+罗红霉素,对照组患者给予地塞米松+维生素E+维生素C,1个疗程之后,检测血清及宫颈抗精子抗体(AsAb)治疗前后的变化、患者的血清炎性介质因子IL-6、肿瘤坏死因子TNF-α的变化.结果 2组在分别给药治疗后,研究组的临床疗效显著优于对照组,差异有统计学意义(P<0.05);2组治疗后血清中AsAb、宫颈处AsAb水平均显著低于对照组,差异有统计学意义(P<0.05);2组在治疗后血清中IL-6、TNF-α比较,研究组显著低于对照组,差异有统计学意义(P<0.05).结论 女性抗精子免疫性不孕与慢性生殖道炎症具有一定的相关性,联合使用抗生素治疗对于女性抗精子免疫性不孕具有显著疗效.
Abstract
Objective To investigate relationship between anti-sperm immune infertility and chronic inflammation in female reproductive tract.Methods80 patients of anti-sperm immunity infertility were selected, and randomly divided into the study group and the control group.The study group was treated with dexamethasone+Vitamin E+Vitamin C+roxithromycin, the control group was treated with dexamethasone+vitamin E+vitamin C, After a course of treatment, serum IL-6, TNF-α and the AsAb in serum and cervix change was detected before and after treatment.ResultsThe clinical efficacy of study group was significantly better than the control group, with statistical significance (P<0.05).the AsAb in serum and cervix in the study group was significantly lower than the control group, with a statistically significant difference (P<0.05).serum IL-6, TNF-α in the study group was significantly lower than the control group, with significant difference (P<0.05).ConclusionThe female anti-sperm immune infertility and the chronic inflammation in female reproductive tract are relational, The female anti-sperm immune infertility combined with antibiotic has a significant effect.
关键词
抗精子免疫性不孕/慢性生殖道炎症/临床效果/抗生素Key words
anti-sperm immune infertility/chronic inflammation in female reproductive tract/clinical effect/antibiotic.引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据