首页|替米沙坦胶囊联合苯磺酸左旋氨氯地平片治疗高血压患者的疗效与安全性

替米沙坦胶囊联合苯磺酸左旋氨氯地平片治疗高血压患者的疗效与安全性

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目的 探讨替米沙坦胶囊联合苯磺酸左旋氨氯地平片治疗高血压患者的疗效与安全性.方法 选择在天津医科大学第二医院治疗的87例原发性高血压患者进行随机分组对照研究.对照组43例患者予苯磺酸左旋氨氯地平片2.5~5mg/d口服,实验组44患者在此基础上联合替米沙坦胶囊40~80mg/d口服,总疗程为8周.比较治疗前后患者的血压水平变化以及治疗有效率和用药后不良反应情况,来评价苯磺酸左旋氨氯地平片联合替米沙坦胶囊治疗高血压的临床疗效.结果 治疗后,2组3种血压指标均明显降低(P<0.05),与对照组相比,实验组患者治疗后血压水平较低(P<0.05).治疗8周后,对照组总有效率为72.09%,实验组总有效率为95.45%,实验组的总有效率高于对照组(P<0.05).治疗后,对照组患者有头痛2例(4.65%),下肢水肿2例(4.65%);实验组患者有眩晕2例(4.55%),关节痛3例(6.82%).2组患者的总不良反应率比较差异无统计学意义.结论 替米沙坦胶囊联合苯磺酸左旋氨氯地平片治疗高血压患者的疗效更显著,安全性更高.
Analysis of clinical efficacy of amlodipine combined with telmisartan capsules in the treatment of hypertension
Objective To investigate the clinical effect of amlodipine combined with Telmisartan Capsules in the treatment of hypertension.MethodsThe patients with primary hypertension in 87 cases in the second hospital affiliated to Tianjin Medical University were divided into two groups.43 patients in control group were treated with amlodipine 2.5~5mg/d orally, 44 patients in the experimental group on the basis of combined with Telmisartan Capsules 40~80mg/d orally, the total course of treatment was eight weeks.The changes of blood pressure levels were compared before and after treatment, the effective rate of the treatment and adverse reactions after treatment, to evaluate the clinical efficacy of amlodipine combined with Telmisartan Capsules in the treatment of hypertension.ResultsAfter treatment, two groups of three blood pressure index were significantly decreased (P<0.05), compared with the control group, the experimental group of patients with treatment After treatment the blood pressure level is low(P<0.05).After eight weeks of treatment, the total efficiency of control group was 72.09%, the total efficiency of experimental group was 95.45%, the experimental group was higher than that in the control group (P<0.05) after treatment, patients in the control group with two cases of headache (4.65%), two cases of lower extremity edema (4.65%);the experimental group of two cases of vertigo (4.55%), three cases of joint pain (6.82%), there was no significant difference in total adverse reaction rate between the two groups.Conclusion Amlodipine combined with Telmisartan Capsules in the treatment of hypertension has good clinical effect.

levamlodipine besylatetelmisartanhypertensionclinical efficacy

董福强、滕广帅

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天津医科大学第二医院心脏科,天津300000

天津市第二儿童医院呼吸科,天津300400

苯磺酸左旋氨氯地平 替米沙坦 高血压 临床疗效

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(5)
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