消瘀康胶囊对上肢骨骨折愈合的影响观察
Observing the effect of Xiaoyukang capsule on the treatment of limb fracture healing
魏勇 1李钧 1金成1
作者信息
- 1. 武警浙江省总队嘉兴医院骨科,浙江嘉兴314000
- 折叠
摘要
目的 本次研究以促进患者上肢骨骨折愈合为目的,分析消瘀康胶囊对上肢骨骨折愈合的疗效.方法 将连续入选的符合上肢骨骨折诊断标准的65例患者按照随机双盲法分为观察组(n=33)和对照组(n=32),观察组患者术后给予消瘀康胶囊进行治疗,对照组患者不做特殊处理.于不同时点对所有患者进行视觉模拟评分(VAS评分)、骨折线评分和骨折愈合程度X线分级,使用Elisa法对骨钙素和总Ⅰ型胶原氨基端延长肽(TPINP)的水平进行测定,分析2组数据的差异性.结果 ①观察组患者术后第3天、术后第7天、术后第10天VAS评分均低于对照组[(3.49±0.31)分比(4.69±0.46)分,P<0.05;(2.40±0.25)分比(3.54±0.35)分,P<0.05;(1.33±0.14)分比(2.42±0.27)分,P<0.05].②观察组患者术后第8周、术后第12周、术后第16周骨折线评分均高于对照组[(1.59±0.27)分比(1.01±0.21)分,P<0.05;(2.65±0.40)分比(1.96±0.36)分,P<0.05;(3.45±0.46)分比(2.65±0.41)分,P<0.05].③观察组患者术后第8周的骨钙素和TPINP水平均高于对照组[(65.37±8.07)μg/L比(39.95±7.18)μg/L,P<0.05;(81.05±6.89)ng/mL比(39.95±7.18)μg/L,P<0.05].④观察组术后第8周骨折愈合程度X线分级(Ⅲ级+Ⅳ级)为23例(69.70%)高于对照组12例(37.50%),且差异具有统计学意义(P<0.05).结论 上肢骨骨折患者术后服用消瘀康胶囊可减轻疼痛感,调节体内骨钙素和TPINP的水平,促进骨折愈合.
Abstract
Objective To observe the effect of Xiaoyukang capsule on the treatment of limb fracture healing.Methods65 patients according to randomized double-blind were divided into two groups (n=33) and control group (n=32 patients), postoperative observation group Xiaoyukang capsule treatment, control group were not special treatment.At different time points in all patients visual analog scale (VAS score), fracture healing fracture line score and grade the degree of X-ray, using Elisa method of total osteocalcin and collagen type I amino-terminal extension of a peptide levels (TPINP) was measured analysis of two sets of data differences.ResultsThe patients in the observation group 3 days, 7 days after, 10 days after VAS scores were lower than the control group[(3.49±0.31) points vs.4.69±0.46 points](P<0.05);[(2.40±0.25) points vs.(3.54±0.35)points](P<0.05);(1.33±0.14) points than (2.42±0.27) points, P<0.05).Patients observed Group 8 weeks, 12 weeks, 16 weeks after the fracture line rates were higher (1.59±0.27 points than (1.01±0.21) points(P<0.05);(2.65±0.40) points than (1.96 ± 0.36)min, P<0.05;(3.45±0.46) points than (2.65 ± 0.41) points(P<0.05).③ patients after 8 weeks of observation group and TPINP water osteocalcin were higher (65.37±8.07)μg/L ratio(39.95±7.18)μg/L(P<0.05);[(81.05±6.89)ng /mL ratio of (39.95±7.18) μg/L] (P<0.05).④ observation group 8 weeks after fracture healing X-ray grade level 69.70% than the control group 37.50%, and the difference was significant (P<0.05).Conclusionlimb fracture patients after taking the capsules Xiaoyu relieve pain, regulate the body and osteocalcin levels TPINP to promote fracture healing.
关键词
消瘀康胶囊/骨折愈合/Ⅰ型胶原氨基端延长肽/骨钙素Key words
Xiaoyukang capsules/fracture healing/Ⅰ collagen amino-terminal extension of apeptide/osteocalcin引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据