首页|阿托伐他汀钙对脑梗死患者血流颈动脉斑块的影响分析

阿托伐他汀钙对脑梗死患者血流颈动脉斑块的影响分析

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目的 观察阿托伐他汀钙用于治疗脑梗死患者颈动脉斑块的临床效果.方法 随机选取2015年1月~2016年1月于金华广福医院就诊的动脉硬化脑梗死患者112例,按数字法分为观察组(n=56)和对照组(n=56),对照组患者给予桂哌齐特治疗,持续6个月,观察组在对照组基础上加用阿托伐他汀钙20mg/d,持续6个月,比较2组患者的临床疗效、血脂水平及对血流流变指标的影响.结果 观察组总有效率为89.28%(50/56)高于对照组69.65%(39/56),2组患者临床疗效比较,差异有统计学意义(P<0.05);治疗后,2组患者血液流变学指标和血脂水平明显改善(P<0.05);且观察组血脂水平及血液流变学改善效果优于对照组(P<0.05).结论 阿托伐他汀有效改善血脂代谢、促进脑血流循环,具有抗颈部动脉粥样硬化的作用,并能稳定颈动脉易损斑块,且安全性较好.
Effect of atorvastatin calcium on carotid plaque in patients with cerebral infarction
Objective To observe the clinical effect of atorvastatin calcium on carotid plaque in patients with cerebral infarction.Methods112 cases of arteriosclerosis in patients with cerebral infarction were randomLy selected from January 2015 to 2016 year in January in our hospital, according to digital method, divided into the observation group (n=56) and control group (n=56), the control group were treated with cinepazide treatment lasted 6 months, the observation group in the control group based on the use of atorvastatin calcium 20mg/d.For 6 months, clinical curative effect and compared two groups of patients with blood lipid levels and blood rheology indexes.ResultsThe total efficiency of the observation group was 89.28% higher than that of the control group (50/56) 69.65% (39/56);to compare the clinical efficacy of the two groups, the difference was statistically significant (P<0.05);the two groups of patients after treatment, blood rheology and blood lipid levels were significantly improved (P<0.05);and the observation group blood lipid levels and blood rheology the improvement is better than the control group (P<0.05).Conclusionatorvastatin can improve the metabolism of blood lipid, promote the circulation of cerebral blood flow, and has the function of resisting carotid atherosclerosis.

atorvastatin calcium sodiumatherosclerotic cerebral infarctionhemorheologyblood lipid level

周百桂

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金华广福医院神经内科,浙江金华321000

阿托伐他汀钙钠 动脉硬化性脑梗死 血液流变学 血脂水平

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(5)
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