目的 评价普拉克索联合舒肝解郁胶囊治疗帕金森病(parkinson's disease, PD)抑郁的效果.方法 根据入选及排除标准收集了2014年6月~2016年4月在杭州师范大学附属医院神经内科门诊就诊的63例病例,35例仅使用普拉克索抗抑郁治疗,设为普拉克索组,28例使用普拉克索联合舒肝解郁胶囊抗抑郁治疗,设为联合治疗组,通过在持续用药6周和9周时进行的汉密尔顿抑郁评分(Hamilton depression scale, HAMD)、日常生活能力量表(activities of daily living, ADL)以及统一帕金森病评分第三部分(unified Parkinson's disease rating scale-part III, UPDRS-III)的评分判断治疗效果.结果 用药9周后普拉克索组HAMD分值为(17.71±6.78)分,联合治疗组HAMD分值为(14.32±4.81)分,2组有统计学差异(P=0.029),2组的HAMDΔ9有统计学差异,普拉克索组(-11.06±3.27),联合治疗组(-14.93±6.24),P=0.002.2组患者的ADLΔ6有显著差异,普拉克索组(-2.37±1.31),联合治疗组(-3.57±2.04),P=0.006,2组患者的UPDRS-III评分有改善,但2组间无统计学差异.2组患者在用药过程中未出现严重不良反应.结论 普拉克索联合舒肝解郁胶囊治疗PD抑郁可以让患者更好的获益.
The effect of Shugan-Jieyu capsule combined with pramipexole in treatment of parkinson's disease depression
Objective Evaluating the effect of Shugan-Jieyu capsule combined with pramipexole on depressive symptoms in parkinson's disease(PD) patients.MethodsAccording to the criteria of including and excluding, we collected 63 PD depression cases who visited doctors at neurological outpatient room between June 2014 and April 2016.35 cases only treated with pramipexole, designed as pramipexole group, and 28 cases treated with pramipexole and Shugan-Jieyu capsule, designed as combined treatment group.The Hamilton depression scale(HAMD), activities of daily living scale(ADL) and unified Parkinson's disease rating scale-part III(UPDRS-III) were assessed at baseling, week 6 and week 9.ResultsAt week 9, HAMD was (17.71±6.78) in pramipexole group versus (14.32±4.81) in combined treatment group, there was significant difference between the two groups(P=0.029), As for HAMDΔ9, analysis did show a significant difference(pramipexole group (-11.06±3.27) vs combined group (-14.93±6.24);P=0.002).Analysis showed a significant difference as for ADLΔ6(pramipexole group (-2.37±1.31) vs combined group (-3.57±2.04);P=0.006) at week 6.There was no significant difference between groups for the reduction in total UPDRS-III scale.No serious adverse event was recorded during treatment of depression.ConclusionShugan-Jieyu capsule combined with pramipexole did have significant effects versus pramipexole on depressive symptoms in PD patients.
NETL
NSTL
万方数据
维普
