C-erbB-2、p-Akt蛋白表达与乳腺癌NAC疗效关系探讨
Relationship between C-erbB-2, p-Akt protein expression and the efficacy of NAC in breast cancer
房国涛 1张琪2
作者信息
- 1. 河北大学附属医院肿瘤科,河北保定071000
- 2. 河北大学医学院临床医学系,河北保定071000
- 折叠
摘要
目的 探讨乳腺癌组织中人表皮生长因子受体-2(C-erbB-2)、磷酸化蛋白激酶B(p-Akt)表达水平与患者新辅助化疗(NAC)效果的关系.方法 选取2014年5月~2015年12月在河北大学附属医院肿瘤科进行手术治疗的114例乳腺癌患者,采用免疫组化染色检测患者NAC治疗前后乳腺癌组织中C-erbB-2、p-Akt蛋白表达水平,分析其与患者临床病理特征、NAC近期疗效的关系.结果 114例患者中C-erbB-2阳性79例(69.30%)、p-Akt阳性77例(67.54%),乳腺癌组织中C-erbB-2阳性率、p-Akt阳性率主要与肿瘤分化程度、是否发生淋巴结转移相关(P<0.05);C-erbB-2阴性表达患者的NAC总有效率80.00%显著的高于阳性患者的54.43%(P<0.05);p-Akt阴性表达患者的NAC总有效率75.68%显著的高于阳性患者的55.84%(P<0.05).结论 乳腺癌组织中C-erbB-2、p-Akt蛋白高表达降低了NAC治疗的敏感性,效果不佳.
Abstract
Objective To investigate the relationship between the expression of human epidermal growth factor receptor-2 (C-erbB-2), phosphorylated protein kinase B (p-Akt) and the effect of neoadjuvant chemotherapy (NAC) in breast cancer.MethodsSelected May 2014 to December 2015 in quasi in our hospital for surgical treatment of 114 cases of patients with breast cancer research, the immunity group dyeing expression levels of C-erbB-2 and p-Akt detection NAC patients before treatment in breast cancer, its relationship with the clinicopathological features of patients, NAC recent curative effect analysis.Results114 patients c-erbB-2 positive 79 cases 69.30% p-Akt positive in 77 cases (67.54%) and breast cancer c-erbB-2 positive rate, p-Akt positive rate of main and tumor differentiation degree, the occurrence of lymph node metastasis (P<0.05);negative c-erbB-2 expression in patients with NAC total effectiveness 80.00% significantly higher than the 54.43% of positive patients (P<0.05);p-Akt negative expression patients with NAC total efficiency 75.68% significantly higher than positive patients of 55.84% (P<0.05).ConclusionThe high expression of p-Akt and C-erbB-2 protein in breast cancer tissue decreased the sensitivity of NAC treatment, and the effect was not good.
关键词
人表皮生长因子受体-2/磷酸化蛋白激酶B/乳腺癌/新辅助化疗Key words
human epidermal growth factor receptor-2/phosphorylated protein kinase B/breast cancer/neoadjuvant chemotherapy引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据