首页|低分子肝素联合阿司匹林、尿激酶治疗急性心肌梗死的有效性和安全性

低分子肝素联合阿司匹林、尿激酶治疗急性心肌梗死的有效性和安全性

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目的 探讨低分子肝素联合阿司匹林与尿激酶治疗急性心肌梗死的有效性和安全性.方法 选择新疆医科大学第一附属医院2013年1月~2016年1月收治的80例急性心肌梗死患者,随机分成对照组与观察组,各40例,对照组给予低分子肝素联合肠溶阿司匹林治疗;观察组在对照组基础上给予静脉溶栓尿激酶治疗.观察比较2组血管再通率、血清因子水平变化、治疗效果及并发症发生情况.结果 观察组血管再通率及总有效率均显著高于对照组(P<0.05);治疗后,2组血清IL-6、IL-8、IL-10及HSP70水平均显著降低,且观察组血清因子改善情况均显著优于对照组(P<0.05);观察组治疗后并发症及急性期病死率均明显低于对照组(P<0.05).结论 低分子肝素联合阿司匹林与尿激酶治疗急性心肌梗死,能有效提高冠状动脉开通率,降低并发症发生率,安全可靠,值得临床推广.
Efficacy and safety of low molecular weight heparin combined with aspirin and urokinase in the treatment of acute myocardial infarction
Objective To investigate the efficacy and safety of low molecular weight heparin combined with aspirin and urokinase in the treatment of acute myocardial infarction.MethodsEighty patients with acute myocardial infarction were randomly divided into control group and observation group.Forty patients in the first affiliated hospital of Xinjiang Medical University from January 2013 to January 2016 were randomly divided into control group and observation group.Forty patients were treated with low molecular weight heparin combined with enteric-coated aspirin;Observation group in the control group based on intravenous thrombolytic therapy.The changes of blood vessel recanalization rate, serum factor level, treatment effect and complication were observed and compared.ResultsThe levels of serum IL-6, IL-8, IL-10 and HSP70 in the two groups were significantly lower than those in the control group (P<0.05).The postoperative complications and acute mortality were significantly lower in the observation group than in the control group (P<0.05).ConclusionLow molecular weight heparin combined with aspirin and urokinase in the treatment of acute myocardial infarction can effectively improve the rate of coronary artery opening, reduce the incidence of complications, safe and reliable, worthy of clinical promotion.

low molecular weight heparinaspirinurokinaseacute myocardial infarctionefficacysafety

古丽斯坦木扎拜尔、吾儿古丽·买买提、阿依仙木古丽·木沙

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新疆医科大学第一附属医院急救创伤中心,新疆维吾尔自治区乌鲁木齐830011

低分子肝素 阿司匹林 尿激酶 急性心肌梗死 有效性 安全性

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(5)
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