首页|不同血液净化方案下重度急性有机磷农药中毒患者的心肌状况对比

不同血液净化方案下重度急性有机磷农药中毒患者的心肌状况对比

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目的 探究单独血液灌流与血液灌流联合连续性静脉-静脉血液滤过(序贯血液净化)对重度急性有机磷农药中毒患者心肌损伤的疗效差异.方法 回顾性分析于2013年7月~2015年7月在温州市人民医院就诊并进行治疗的重度急性有机磷农药中毒患者共94例,根据患者血液净化方案的不同,将患者分为血液灌流组(n=48)与序贯血液净化组(n=46),对比治疗结束后2组临床疗效、心肌谱指标状况及并发症情况.结果 治疗后,血液灌流组左心室射血分数为(53.8±5.8)%,序贯血液净化组治疗后左心室射血分数为(58.1±3.4)%,二者有明显差异,具有统计学意义(P<0.05).在心肌酶谱指标方面,且序贯血液净化组患者心肌酶谱指标明显优于血液灌流组(P<0.05).序贯血液净化组患者各项并发症发生率均低于血液灌流组(P<0.05).结论 采用血液灌流联合连续性静脉-静脉血液滤过的血液净化方案治疗重度急性有机磷农药中毒患者能够显著改善治疗效果.
Comparison of cardiac muscle status in patients with severe acute organophosphorus pesticide poisoning under different blood purification schemes
Objective To explore the effect of single blood perfusion combined with blood perfusion combined with continuous venous venous blood filtration (sequential blood purification) on myocardial injury in patients with severe acute organophosphorus pesticide poisoning.MethodsRetrospectively analyzed in July 2013 to July 2015 treated in our hospital see a doctor and a total of 94 patients with severe acute organophosphorus pesticide poisoning, depending on the patient's blood purification scheme, divided the patients into blood perfusion group (n=48) and sequential blood purification group (n=46), contrast after treatment on two groups of clinical curative effect, the condition of myocardial spectrum index and its complications.ResultsAfter treatment, blood perfusion group of left ventricular ejection fraction was (53.8±5.8)%, sequential left ventricular ejection fraction after blood purification treatment group was (58.1±3.4)%, both have obvious difference, has statistics meaning (P<0.05).In terms of myocardial enzyme spectrum index, and sequential blood purification group is obviously better than the index of myocardial enzymes in patients with blood perfusion group (P<0.05).The incidence of complications in patients with sequential blood purification group were lower than the blood perfusion group (P<0.05).ConclusionThe joint continuity venous blood perfusion-blood purification scheme of vein hemofiltration treatment of patients with severe acute organophosphorus pesticide poisoning can significantly improve treatment effect.

blood perfusionsequential blood purificationsevere acute organophosphorus pesticide poisoningmyocardial damage

林强康、杨絮、林岳、陈新国

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温州市人民医院急诊科,浙江温州325000

血液灌流 序贯血液净化 重度急性有机磷农药中毒 心肌损害

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(5)
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