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黄酮类化合物药理作用的探讨

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目的 探讨黄酮类化合物的药理作用和临床治疗应用.方法 对黄酮类化合物的药理作用进行研究分析,查找检索相关参考文献,进行分析总结,使其达到临床的应用目的.阐述黄酮类药物的药理作用机制和临床应用,分析其生物活性,结合相关结构功能,对黄酮类化合物的研究进行更深入的阐述.结果 经过分析后,黄酮类化合物的药理作用对人体的心血管系统、消化系统、神经系统、免疫调节系统等有一定的影响.黄酮类化合物对神经系统的作用主要体现在镇痛、抗抑郁以及延缓衰老.黄酮类化合物的抗菌抗病毒作用主要指的是抗菌、抗病毒活性以及抗HIV活性.黄酮类化合物对肝的各种损伤有很好的保护作用,如化学性肝损伤、酒精性肝损伤、免疫性肝损伤、再灌注性肝损伤等.黄酮类化合物对肿瘤细胞的生长和繁殖具有显著的抑制作用,能够在很大程度上促进抑癌基因的表达、促进抗肿瘤细胞的繁殖等.黄酮类化合物中与雌激素化学结构相似的是异黄酮,具有雌激素的生理作用,从而对雌激素有一定的调节作用.结论 黄酮是从多种植物中提取出来的,属于多酚化合物,具有一定的生物活性,对其药理作用进行总结分析可便于在临床上应用,具有抗炎、抗肿瘤、免疫调节以及保护肝和镇痛等多方面的应用,生物活性多样,临床应用较为广泛.
Study on pharmacological action of flavonoids
Objective To study the pharmacological action and clinical application of flavonoids.MethodsThe pharmacological effects of flavonoids were analyzed, and the related literatures were searched and analyzed.This paper describes the pharmacological action mechanism and clinical application of flavonoids, analyzes its biological activity, combined with the related structure and function, and gives a more detailed description of the study of flavonoids.ResultsAfter analysis, the pharmacological effects of flavonoids on human cardiovascular system, digestive system, nervous system, immune system, and so on have a certain impact.The effect of flavonoids on the nervous system is mainly manifested in the analgesic, anti-inhibition and anti-aging.The antibacterial and antiviral effects of flavonoids are mainly antibacterial, antiviral activity and anti HIV activity.Flavonoids have good protective effects on liver injury, such as chemical liver injury, alcoholic liver injury, immunological liver injury, reperfusion liver injury and so on.Flavonoids can inhibit the growth and reproduction of tumor cells, and can promote the expression of tumor suppressor genes and promote the proliferation of tumor cells.The chemical structure of flavonoids is similar to that of estrogen, which is a kind of isoflavone, which has the physiological action of estrogen, and has a certain effect on estrogen.ConclusionThe flavone is extracted from various plants, belonging to the polyphenol compounds, with certain biological activity, were analyzed for the clinical application of its pharmacological action, has many applications of anti-inflammatory, anti-tumor, immunoregulation and liver protection and analgesic, a variety of biological activity, is widely applied in clinical.

flavonoidspharmacological effects

郑海燕、王晓杰

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温州医科大学药学院,浙江温州325000

黄酮类化合物 药理作用

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(5)
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