促性腺激素释放激素激动剂对早期宫颈癌行保留卵巢根治术患者卵巢功能的保护作用
Protective effects of gonadotropin releasing hormone agonist on ovarian function in patients with early stage cervical cancer undergoing ovarian preservation
朱科妙 1陈小萍 1付玉玲1
作者信息
- 1. 宁波市鄞州区第二医院 妇产科,浙江 宁波 315100
- 折叠
摘要
目的 探究促性腺激素释放激素激动剂对早期宫颈癌行保留卵巢根治术患者卵巢功能的保护作用.方法 选取宁波市鄞州第二医院妇产科在2015年1月~2016年1月期间收治的早期宫颈癌患者共80例,随机分为对照组和观察组,观察组患者进行保留卵巢根治术,同时给予促性腺激素释放激素(GnRH)激动剂治疗,对照组患者仅进行保留卵巢根治术,比较2组患者化疗前后基础卵泡刺激素(bFSH)水平、血清抗苗勒管激素(AMH)水平、基础雌激素(bE2)水平和基础窦状卵泡数(bAFC).结果 2组患者化疗前bFSH和bE2水平均无显著差异,化疗后观察组患者bFSH和bE2水平均显著低于对照组(P<0.05),且化疗后2组患者bFSH水平均高于化疗前,bE2水平均低于化疗前(P<0.05);化疗前2组患者AMH水平和bAFC比较差异无统计学意义,化疗后观察组患者AMH水平和bAFC数均显著高于对照组(P<0.05),且化疗后2组患者AMH水平和bAFC数均低于化疗前(P<0.05).结论 GnRH激动剂可以有效保护早期宫颈癌行保留卵巢根治术患者的卵巢储备功能,临床上值得进一步推广应用.
Abstract
Objective To investigate the protective effect of gonadotropin releasing hormone agonist on ovarian function in patients with early stage cervical cancer.Methods80 cases ofadmitted patients with early stage cervical cancerfrom January 2015 to January 2016 in Yinzhou Second Hospital were selected, were randomly divided to observation group and control group.Patients in the observation group were retained ovarian resection, while giving the gonadotropin releasing hormone (GnRH) agonist treatment, the control group patients only with reservation of ovary resection and compared between the two groups before and after chemotherapy in patients with basal follicle stimulation hormone (bFSH) levels, serum anti Mullerian tube hormone (AMH) level, basic estrogen (bE2) levels, and the basal antral follicle number (bafc).ResultsThere were no significant differences in two groups of chemotherapy in patients with anterior bFSH and bE2 level, after chemotherapy, the observation group patients bFSH and bE2 level was significantly lower than that in control group (P<0.05) and chemotherapy after bFSH level of two groups of patients were higher than that in the chemotherapy before.bE2 levels were lower than those before chemotherapy (P<0.05);chemotherapy the number of patients in the two groups of AMH level and bafc without significant difference, after chemotherapy, the observation group AMH levels and bafc number were significantly higher than those of the control group (P<0.05) and chemotherapy after two groups of patients with AMH levels and bafc number lower than the chemotherapy before (P<0.05).ConclusionGnRH agonists can effectively protect the early cervical cancer patients with radical resection of ovarian reserve and ovarian reserve function, clinical application is worthy of further promotion.
关键词
促性腺激素释放激素激动剂/早期宫颈癌/卵巢根治术/卵巢功能Key words
gonadotropin releasing hormone agonist/early stage cervical cancer/ovarian radical operation/ovarian function引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据