2型糖尿病合并抑郁患者炎性因子和胰岛素抵抗指数的变化及其临床意义
Changes of inflammatory factors and insulin resistance index in patients with type 2 diabetes mellitus complicated by depression and its clinical significance
程雅洁 1温建艳 1田晓利 1周文聪1
作者信息
- 1. 浙江省青田县人民医院 检验科,浙江 丽水 323902
- 折叠
摘要
目的 探讨2型糖尿病合并抑郁患者机体炎性因子、胰岛素抵抗指数检测特点及意义.方法 研究组2型糖尿病合并抑郁患者、对照1组2型糖尿病未合并抑郁患者、对照2组抑郁未合并糖尿病患者、对照3组健康人群均接受IL-2、TNF-α、HOMA-IR检测,记录其上述指标检测结果.结果 经分析可知研究组IL-2、TNF-α、HOMA-IR均最高(P<0.05);对照1组、对照2组IL-2、TNF-α、HOMA-IR检测结果显著高于对照3组,而较研究组显著降低(P<0.05),此2组间上述指标对比差异无统计学意义.结论 2型糖尿病合并抑郁患者机体内将存在较高水平的胰岛素抵抗指数及炎症因子,因此提示对2型糖尿病患者积极给予抗炎、改善胰岛素抵抗等对症治疗将获得较为理想的抑郁症预防效果.
Abstract
Objective To investigate the characteristics and significance of inflammatory factors and insulin resistance index in patients with type 2 diabetes mellitus complicated with depression.MethodsThe patients with type 2 diabetes mellitus complicated with depression were treated with IL-2, TNF-α and HOMA-IR in control group.The patients in type 2 diabetes mellitus had no complication and depression., Record the above indicators of test results.ResultsIL-2, TNF-α and HOMA-IR were the highest in the study group (P<0.05).The levels of IL-2, TNF-α and HOMA-IR in control group 1 and control group 2 were significantly higher than those in control group (P<0.05).There was no significant difference between the two groups.ConclusionThere is a high level of insulin resistance index and inflammatory factor in patients with type 2 diabetes mellitus complicated with depression.Therefore, it is suggested that the treatment of type 2 diabetes mellitus can be treated with anti-inflammatory and insulin resistance.The.
关键词
2型糖尿病/抑郁/炎性因子/胰岛素抵抗指数/临床检验/应用价值Key words
type 2 diabetes mellitus/depression/inflammatory factors/insulin resistance index/clinical test/applied value引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据