首页|克拉霉素联合香菊胶囊对慢性鼻窦炎患者的临床疗效及安全性观察

克拉霉素联合香菊胶囊对慢性鼻窦炎患者的临床疗效及安全性观察

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目的 观察应用克拉霉素联合香菊胶囊治疗慢性鼻窦炎的效果.方法 收集2014年5月~2016年9月宁波市第九医院接收的慢性鼻窦炎病例共106例,随机分为试验组与对照组各53例.试验组联合应用克拉霉素与香菊胶囊进行治疗,对照组单用克拉霉素进行治疗.观察2组鼻窦CT评分的变化情况,比较用药安全性等指标.结果 试验组用药后的鼻窦CT评分为(2.64±0.53)分,对照组评分为(4.52±0.46)分,试验组明显低于对照组,差异具有统计学意义(P<0.05).试验组疗效总有效率、鼻窦CT评分疗效总有效率分别是96.23%、94.34%,均明显高于对照组(66.04%、64.15%),差异具有统计学意义(P<0.05).2组用药后不良反应发生率比较差异无统计学意义.用药后的主要症状积分,试验组明显比对照组低,差异具有统计学意义(P<0.05).结论 于常规克拉霉素治疗慢性鼻窦炎的基础上,对患者辅以香菊胶囊治疗,既利于其鼻窦CT评分的改善,又能提高临床疗效,且还不会增加药物不良反应,值得临床借鉴.
Clinical efficacy and safety of clarithromycin combined with fragrant chrysanthemum capsule in patients with chronic sinusitis
Objective To observe the effect of clarithromycin combined with fragrant chrysanthemum capsule in chronic sinusitis.MethodsFrom May 2014 to September 2016 in our hospital received chronic sinusitis in 106 cases were randomly divided into test and control group two, 53 cases each.The experimental group was combined with clarithromycin and Xiangju capsule, control group was treated with clarithromycin.Two changes of sinus CT score of observation group, compared with the drug safety index.ResultsSinus CT after treatment in the experimental group was (2.64±0.53), control group (4.52±0.46), the test group was significantly lower than the control group, the difference was statistically significant (P< 0.05).The experimental group total effective rate, sinus CT score total effective rate were 96.23%, 94.34%, were significantly higher than the control group (66.04%, 64.15%), the difference was statistically significant (P< 0.05).Two groups of incidence of adverse drug reactions had no statistically significant difference.The main symptoms after treatment points were significantly lower than the control group, the difference was statistically significant (P< 0.05).ConclusionBased on the conventional clarithromycin in the treatment of chronic sinusitis, the patients were treated with Xiangju capsule treatment, is conducive to the improvement of sinus CT score, and can improve the clinical efficacy, and also does not increase the side effects of drugs, which is worthy of reference.

chrysanthemum capsulesafetychronic sinusitisclarithromycin

皇甫劲

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浙江省宁波市第九医院 药剂科,浙江 宁波 315000

香菊胶囊 安全性 慢性鼻窦炎 克拉霉素

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(6)
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