米托蒽醌对前列腺癌骨痛缓解情况、临床疗效及安全性分析
The effect of mitoxantrone on prostate cancer and analysis of pain relief
易虎 1赵明 1何锦华1
作者信息
- 1. 天津中医药大学第一附属医院 泌尿外科,天津 300192
- 折叠
摘要
目的 探讨米托蒽醌对前列腺癌的治疗效果及对缓解患者骨痛的效果.方法 回顾性分析2010年4月~2016年5月在天津中医药大学第一附属医院接受治疗的前列腺癌伴骨痛患者的临床资料,根据其治疗方式分为对照组和观察组,其中对照组40例,给予多西他赛治疗,观察组30例,给予米托蒽醌治疗.治疗2个疗程后,比较2组患者骨痛控制情况、睡眠质量、肿瘤标志物水平和不良反应发生率的差别.结果 治疗后,观察组骨痛控制有效率为96.67%,明显高于对照组,差异有统计学意义(P<0.05);观察组睡眠质量明显优于对照组,差异有统计学意义(P<0.05);观察组cPSA和CEA水平低于对照组,差异有统计学意义(P<0.05);2组患者骨髓抑制、恶心呕吐、皮疹和液体潴留发生率无明显差别(χ2=0.648,P=0.421).结论 米托蒽醌对前列腺癌有较好的治疗效果,可明显缓解患者骨痛情况和睡眠质量.
Abstract
Objective To investigate the therapeutic effect of mitoxantrone on prostate cancer and the effect of relieving pain of patients.MethodsRetrospective analysis of clinical data of patients with bone pain in April 2010 to May 2016 year in our hospital for treatment of prostate cancer, according to their treatment divided into control group and observation group, the control group was 40 cases given docetaxel treatment, the observation group was 30 cases treated with mitoxantrone.Compared the pain relief, sleep quality, tumor markers and the incidence of adverse reactions of the two groups.ResultsAfter treatment, the observation group pain control rate was 96.67%, significantly higher than the control group, the difference was statistically significant (P<0.05);the observation group sleep quality was significantly better than the control group, the difference was statistically significant (P<0.05);the observation group cPSA and CEA were lower than those of control group, the difference was statistically significant (P<0.05).Two groups of patients with bone marrow suppression, nausea and vomiting, rash and liquid retention rate had no significant difference (χ2=0.648, P=0.421).ConclusionMitoxantrone has better therapeutic effect on prostate cancer, can significantly relieve the situation and quality of sleep in patients with bone pain.
关键词
米托蒽醌/前列腺癌/睡眠质量/肿瘤标志物Key words
mitoxantrone/prostate cancer/sleep quality/tumor markers引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据