中国生化药物杂志2017,Vol.37Issue(6) :183-184,187.DOI:10.3969/j.issn.1005-1678.2017.06.068

B超监测下稽留流产清宫术后服用屈螺酮炔雌醇片对宫腔粘连的临床预防效果

Clinical prevent effect of taking drospirenone and ethinylestradiol tablets on intrauterine adhesion after missed abortion curettage with b-ultrasonic observation

朱长远
中国生化药物杂志2017,Vol.37Issue(6) :183-184,187.DOI:10.3969/j.issn.1005-1678.2017.06.068

B超监测下稽留流产清宫术后服用屈螺酮炔雌醇片对宫腔粘连的临床预防效果

Clinical prevent effect of taking drospirenone and ethinylestradiol tablets on intrauterine adhesion after missed abortion curettage with b-ultrasonic observation

朱长远1
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作者信息

  • 1. 浙江省金华市中医医院 B超室,浙江 金华 321000
  • 折叠

摘要

目的 对B超监测下稽留流产清宫术后服用屈螺酮炔雌醇片,预防宫腔粘连的临床效果进行探讨.方法 将216例B超监测下行稽留流产清宫术研究对象设为对照组108例,术后采取常规治疗;研究组108给予常规治疗、屈螺酮炔雌醇片治疗.比较2组术后情况,治疗后1个月内宫腔粘连情况,治疗1年后的再孕、不孕、流产情况.结果 研究组阴道出血时间、盆腔积液及月经复潮时间均显著低于对照组,差异均有统计学意义(t=6.114,t=9.481,t=9.201,P<0.05);研究组子宫内膜厚度明显大于对照组,差异均有统计学意义(t=14.171,P<0.05).对照组治疗后1周、2周等子宫粘连比例均显著高于研究组,差异均有统计学意义(χ2=5.329,χ2=6.051,P<0.05).2组治疗1年后的再孕率比较,差异无统计学意义(χ2=0.113,P>0.05);对照组和研究组治疗1年后的不孕率、流产率进行比较,对照组明显高于研究组,差异均有统计学意义(χ2=4.317,χ2=5.225,P<0.05).结论 B超监测下稽留流产清宫术后立即服用屈螺酮炔雌醇片,能够有效预防术后宫腔粘连,并且减少流产、不孕等并发症,可根据患者实际情况进行应用.

Abstract

Objective To discuss clinical efficacy of taking drospirenone and ethinylestradiol tablets in preventing intrauterine adhesion after missed abortion curettage with b-ultrasonic observation.Methods216 cases of study objects provided with missed abortion curettage with b-ultrasonic observation were divided into control group with 108 cases and research group with 108 cases.Patients in control group were provided with conventional treatment after surgery, while those in research group were provided with conventional treatment and drospirenone and ethinylestradiol tablets.Two groups were compared for condition after surgery such as intrauterine adhesion in 1month after treatment, secondary pregnancy, infertility and abortion in 1 year after treatment.ResultsTime of vaginal bleeding, pelvic effusion and time of return of menses in research group were significantly lower than those in control group, with difference having statistical significance (t=6.114,t=9.481,t=9.201,P<0.05).Endometrial thickness of research group was distinctly greater than control group, with difference having statistical significance (t=14.171,P<0.05).In 1 week and 2 weeks after treatment, the proportion of uterus adhesion in control group was higher than that in research group, with difference having statistical significance (χ2=5.329,χ2=6.051,P<0.05).The difference in rate of secondary pregnancy in 1 year after treatment between two groups had no statistical significance (χ2=0.113,P>0.05).In the case of infertility rate and rate of abortion in 1 year after treatment, control group was higher than research group with difference having statistical significance (χ2=4.317,χ2=5.225,P<0.05).ConclusionTaking drospirenone and ethinylestradiol tablets after missed abortion curettage with b-ultrasonic observation can effectively prevent intrauterine adhesion, which can also reduce complications such as abortion and infertility, therefore, it shall be applied in accordance with specific condition of patients.

关键词

B超监测/稽留流产/屈螺酮炔雌醇片/宫腔粘连

Key words

B-ultrasonic observation/missed abortion curettage/drospirenone and ethinylestradiol tablets/intrauterine adhesion

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出版年

2017
中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
被引量13
参考文献量7
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