首页|不同噻托溴铵给药方案对成年哮喘患者的疗效比较

不同噻托溴铵给药方案对成年哮喘患者的疗效比较

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目的 分析探讨成年哮喘患者采取不同噻托溴铵给药方法治疗的临床效果以及相关表现.方法 选取山东大学第二医院2014年8月~2016年5月收治入院的成年支气管哮喘发作58例,随机分为观察组和对照组,各29例,2组患者均在常规治疗的基础上采取噻托溴铵治疗,观察组在每晚给予噻托溴铵5μg治疗,对照组采取每日早晚给予噻托溴铵2.5μg治疗,分析对比2组患者的临床效果以及相关表现.结果 2组患者经不同的给药方法治疗后,观察组和对照组的动脉血气分析结果对比有统计学差异,其临床治疗效果对比差异有统计学意义(P<0.05);观察组取得的治疗有效率与对照组取得的治疗有效率对比差异有统计学意义(P<0.05);2组患者经治疗后,观察组患者哮喘临床症状缓解时间为(6.24±1.92)d,而对照组患者为(8.33±2.47)d,2组患者对比差异具有统计学意义(P<0.05).结论 不同噻托溴铵给药方案对成年哮喘患者的疗效均具有显著的临床效果,每晚给予噻托溴铵5μg治疗的患者,其临床效果更为明显.
Comparison of therapeutic effects of different tiotropium bromide regimens in adult patients with asthma
Objective To analyze the clinical effect and the related performance of different tiotropium bromide in the treatment of adult asthma patients.Methods58 patients in the Second hospital of Shandong University from August 2014 to May 2016 admitted to the adult bronchial asthma, were randomly divided into observation group and control group, each of the 29 cases of patients, two patients were taken on the basis of routine treatment of tiotropium bromide in the treatment, the observation group in each given tiotropium 5 g treatment.The control group took a day sooner or later given tiotropium 2.5 g treatment, analysis of clinical effect of two groups were compared and the related performance.ResultsThis group of patients with different delivery methods after treatment, the observation group and the control group of arterial blood gas analysis results have significant difference compared to the clinical effect compared with statistical difference (P<0.05);treatment group the effective rate of treatment group and control the efficiency compared with significant differences (P<0.05);the two groups of patients after treatment, clinical symptoms were observed in groups of patients with asthma remission time were (6.24±1.92) d, while the control group was (8.33±2.47) d, the two groups were compared with statistical difference (P<0.05).ConclusionDifferent tiotropium dosing regimen for adult patients with asthma curative effect has significant clinical effect, compared with 5 per night given tiotropium Gtherapy and its clinical effect is more obvious.

adult asthmatiotropium bromideadministration method

朱秀娟、张斌、张国华

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山东大学第二医院 药学部,山东 济南 250033

成年哮喘 噻托溴铵 给药方法

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(6)
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