Analysis on the influence of ibuprofen and paracetamol on ductus arteriosus closure rate, laboratory parameters and complications risk of preterm infants with PDA
Objective To investigate the influence of ibuprofen and paracetamol on ductus arteriosus closure rate, laboratory parameters and complications risk of preterm infants with PDA.Methods110 preterm infants with PDA were chosen in July 2013 to July 2016 in iwu maternal and child health hospital and randomly divided into two groups.On the basis of conventional intervention, group A (55 cases) were treated with ibuprofen and group B (55 cases) were treated with paracetamol.The ductus arteriosus closure rate, the levels of PGE2, PLT, Cr and ALT before and after treatment and the complications incidence in the two groups were compared.ResultsThere was no significant difference of the ductus arteriosus closure rate between the two groups.The levels of PGE2 after treatment in the two groups were significantly lower than that before treatment(P<0.05).The levels of PGE2 after treatment in group B were significantly higher than that in group A(P<0.05).There was no significant difference of the levels of PLT, Cr and ALT before and after treatment between the two groups.The incidence of oliguresis in group B were significantly lower than that in group A(P<0.05).There was no significant difference of the incidence of positive fecal occult blood test, intraventricular hemorrhage, necrotizing enterocolitis and bronchopulmonary dysplasia between the two groups.ConclusionIbuprofen and paracetamol in the treatment of preterm infants with PDA possess the same effects in promote the arterial closure;Compared with ibuprofen, paracetamol application can efficiently reduce the oliguria risk and improve long-term prognosis.
NETL
NSTL
万方数据
维普
