布洛芬与对乙酰氨基酚对PDA早产儿动脉导管闭合率、实验室指标及并发症风险的影响
Analysis on the influence of ibuprofen and paracetamol on ductus arteriosus closure rate, laboratory parameters and complications risk of preterm infants with PDA
杨拾梅1
作者信息
- 1. 义乌市妇幼保健院 儿内科,浙江 义乌 322000
- 折叠
摘要
目的 探讨布洛芬与对乙酰氨基酚对症状性动脉导管未闭(PDA)早产儿动脉导管闭合率、PEG2水平及并发症风险的影响.方法 研究对象选取义乌市妇幼保健院2013年7月~2016年7月收治PDA早产儿共110例,以随机数字表法分为A组(55例)和B组(55例),分别给予布洛芬与对乙酰氨基酚口服辅助治疗;比较2组患儿动脉导管闭合率、治疗前后PGE2、PLT、Cr、ALT水平及并发症发生率等.结果 2组患儿动脉导管闭合率比较差异无统计学意义;2组患儿治疗后血PGE2和尿PGE2水平显著低于治疗前(P<0.05);B组患儿治疗后血PGE2和尿PGE2水平均显著高于A组(P<0.05);2组患儿治疗前后PLT、Cr及ALT水平比较差异无统计学意义;B组患儿少尿发生率均显著低于A组(P<0.05);2组患儿大便隐血阳性、脑室内出血、坏死性小肠结肠炎及支气管肺发育不良反应发生率比较差异无统计学意义.结论 布洛芬与对乙酰氨基酚用于PDA早产儿治疗在促进导管闭合方面效果接近;但对乙酰氨基酚应用有助于降低少尿发生风险,改善远期预后.
Abstract
Objective To investigate the influence of ibuprofen and paracetamol on ductus arteriosus closure rate, laboratory parameters and complications risk of preterm infants with PDA.Methods110 preterm infants with PDA were chosen in July 2013 to July 2016 in iwu maternal and child health hospital and randomly divided into two groups.On the basis of conventional intervention, group A (55 cases) were treated with ibuprofen and group B (55 cases) were treated with paracetamol.The ductus arteriosus closure rate, the levels of PGE2, PLT, Cr and ALT before and after treatment and the complications incidence in the two groups were compared.ResultsThere was no significant difference of the ductus arteriosus closure rate between the two groups.The levels of PGE2 after treatment in the two groups were significantly lower than that before treatment(P<0.05).The levels of PGE2 after treatment in group B were significantly higher than that in group A(P<0.05).There was no significant difference of the levels of PLT, Cr and ALT before and after treatment between the two groups.The incidence of oliguresis in group B were significantly lower than that in group A(P<0.05).There was no significant difference of the incidence of positive fecal occult blood test, intraventricular hemorrhage, necrotizing enterocolitis and bronchopulmonary dysplasia between the two groups.ConclusionIbuprofen and paracetamol in the treatment of preterm infants with PDA possess the same effects in promote the arterial closure;Compared with ibuprofen, paracetamol application can efficiently reduce the oliguria risk and improve long-term prognosis.
关键词
布洛芬/对乙酰氨基酚/症状性动脉导管未闭/早产儿Key words
ibuprofen/paracetamol/patent ductus arteriosus/premature infant引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据