稳心颗粒联合美托洛尔治疗频发性室性早搏的随机对照研究
Clinical effect of Wenxinkeli combined with metoprolol on frequent ventricular ectopic beats(FVEB): a randomized controlled observation
宋洋 1周静 1高迎华 2张秀静3
作者信息
- 1. 解放军第二六六医院,河北 承德 067000
- 2. 河北省围场县大都医院 内科,河北 承德 068450
- 3. 河北省承德市中医院 内科,河北 承德 067000
- 折叠
摘要
目的 观察稳心颗粒联合美托洛尔治疗频发性室性早搏(frequent ventricular premature beat,FVEB)的临床治疗效果.方法 采用随机双盲的方法将234例FVEB患者分为研究组和对照组,研究组117例给予美托洛尔联合稳心颗粒治疗,对照组117例给予美托洛尔联合安慰剂治疗,2组均以4周为1个疗程.观察患者治疗前和治疗后心率变异性、QT间期离散度和24h平均心率,评价2组的治疗效果.结果 治疗4周后,研究组剔除5例,对照组剔除7例.对照组和研究组有效率分别为89.29%和79.09%(P<0.05).治疗后2组的SDNN、SDANN、RMSSD和PNN50较治疗前明显增高(P<0.05),研究组增加幅度高于对照组(P<0.05).治疗后2组的QTd和QTcd均较治疗前下降(P<0.05),研究组下降幅度高于对照组(P<0.05).治疗前后2组的心率无显著变化.结论 稳心颗粒联合美托洛尔治疗FVEB可延长HRV、降低QTd,提高治疗效果,对心率无明显影响.
Abstract
Objective It is to observe the clinical effect of Wenxinkeli combined with metoprolol on frequent ventricular premature beat (FVEB).Methods234 patients with FVEB were randomly divided into the study group and control group.117 patients in the control group were treated with metoprolol combined with placebo, and 117 patients in the stduy group were treated with Wenxinkeli combined with metoprolol.4 weeks were a course of treatment.After four weeks, the heart rate variability, QT interval dispersion and 24h average heart rate of two groups were observed, and the clinical effect were evaluated.ResultsAfter 4 weeks of treatment, 5 cases in the study group and 7 cases in the control group were excluded.The efficiency of control group and study group were 89.29% and 79.09% (P<0.05), respectively.After treatment, the SDNN、SDANN、RMSSD and PNN50 of two groups were significantly higher than those before treatment(P<0.05), and the increase value of the study group was higher than that of the control group(P<0.05).After treatment, the QTd and QTcd of two groups were decreased than those before treatment(P<0.05), and the decreased value of the study group was higher than that of the control group(P<0.05).There was no significant change in the heart rate of the two groups before and after treatment.ConclusionWenxinkeli combined with metoprolol in the treatment of FVEB can prolong HRV, reduce QTd, improve the treatment effect, has no significant effect on the heart rate.
关键词
频发性室性早搏/美托洛尔/稳心颗粒/随机对照Key words
frequent ventricular ectopic beats/metoprolol/weixinkeli/randomized controlled trial引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据