首页|盐酸利托君对先兆早产患者外周血象及保胎率的影响

盐酸利托君对先兆早产患者外周血象及保胎率的影响

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目的 观察先兆早产患者采取盐酸利托君治疗,对其外周血象及保胎率的影响.方法 选取2015年10月~2016年9月本院诊疗的先兆早产患者89例,随机分为2组,研究组45例,采取盐酸利托君治疗;对照组44例,给予硫酸镁治疗.比较2组外周血象指标、宫缩消失时间、孕期延长天数、产后出血量、新生儿出生体质量、保胎率.结果 治疗后,对照组的CRH、NO、PGE2、IL-8均明显高于研究组,差异均有统计学意义(t=10.826,3.839,7.534,8.075,P均<0.05).对照组宫缩消失时间明显高于研究组,研究组孕期延长天数、新生儿出生天数明显高于对照组,差异均有统计学意义(t=4.566,7.855,3.237,P均<0.05);2组产后出血量比较,差异无统计学意义(t=0.889,P>0.05).研究组保胎总有效率86.7%,明显高于对照组的70.5%,差异具有统计学意义(χ2=7.801,P<0.05).结论 盐酸利托君可有效抑制外周血象中的宫缩因子,延长先兆早产患者孕周天数,从而提高临床保胎率及新生儿出生质量.
Effect of ritodrine hydrochloride on peripheral blood and tocolysis rate of patients with threatened premature labor
Objective To observe the effect of ritodrine hydrochloride on peripheral blood and tocolysis rate of patients with threatened premature labor.Methods89 cases of patients with threatened premature labor were selected from October 2015 to September 2016 and randomly divided into two groups, research group with 45 cases treated with ritodrine hydrochloride and control group with 44 cases treated with epsom salt.The peripheral blood, extinction time of uterine contraction, extended days of pregnancy, postpartum hemorrhage, neonatal birth weight and tocolysis rate were compared between two groups.ResultsAfter treatment, CRH, NO, PGE2 and IL-8 of control group were obviously higher than research group, the difference was statistically significant (t=10.826,3.839,7.534,8.075,P<0.05).The extinction time of uterine contraction in control group was obviously longer than research group, while extended days of pregnancy and neonatal birth days in research group were obviously longer than control group, the difference was statistically significant (t=4.566,7.855,3.237,P<0.05).There was no significant difference in postpartum hemorrhage between two groups (t=0.889,P>0.05).The overall efficacy of tocolysis in control group was 70.5%, while that in research group was 86.7%, which was obviously higher than the control group, the difference was statistically significant (χ2=7.801,P<0.05).ConclusionRitodrine hydrochloride can effectively control uterine contraction factor in peripheral blood and extend gestational days of patients with threatened premature labor, so as to improve tocolysis rate and birth quality.

ritodrine hydrochloridethreatened premature laborperipheral bloodtocolysis

潘莉莉、施江平、刘小媚

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浙江省义乌市妇幼保健计划生育服务中心,浙江 义乌 322000

盐酸利托君 先兆早产 外周血象 保胎

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(6)
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