首页|替格瑞洛与氯吡格雷治疗冠心病心肌缺血的临床疗效对比

替格瑞洛与氯吡格雷治疗冠心病心肌缺血的临床疗效对比

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目的 对比分析替格瑞洛与氯吡格雷治疗冠心病心肌缺血的临床疗效.方法 选取2016年1月~2017年1月于北京市延庆区医院就诊的冠心病心肌缺血患者86例,采用数字随机法,均分为A组(n=43)与B组(n=43),A组患者给予替格瑞洛治疗,B组患者给予氯吡格雷治疗,对比2组患者的临床疗效.结果 A组患者的治疗总有效率86.04%显著高于B组的72.09%,2组比较差异具有统计学意义(P<0.05);A组患者的ST段下降次数(36.17±4.22)次、ST段持续下降时间(120.29±13.53)s、心率(65.27±3.18)次/min、收缩压(105.44±2.17)mmHg、舒张压(63.11±3.14)mmHg均显著低于对照组(P<0.05);A组患者甘油三酯、总胆固醇、血浆粘度切边率、全血粘度低切变率、全血粘度高切变率均显著低于B组(P<0.05).结论 与氯吡格雷相比,替格瑞洛能够有效改善冠心病心肌缺血患者的血液微循环,缓解冠心病病变引起的心肌缺血,临床疗效显著,具有推广使用价值.
Comparison of clinical efficacy between clopidogrel and clopidogrel in the treatment of coronary heart disease with myocardial ischemia
Objective To compare the clinical efficacy of clopidogrel and clopidogrel in the treatment of myocardial ischemia in patients with coronary heart disease (CHD).Methods86 patients with myocardial ischemia of coronary heart disease from January 2016 to January 2017 in our hospital, were randomly divided into group A (n=43) and group B (n=43), group A was treated with ticagrelor treatment, group B was treated with clopidogrel treatment, clinical curative effect were compared between the two groups.ResultsThe total effective rate in group A was 86.04% was significantly higher than 72.09% in group B, the difference was statistically significant (P<0.05);The number of ST segment descent in group A was (36.17±4.22) times,ST segment continuous decline time (120.29 ±13.53) s ST continued to decline time (120.29±13.53) s, heart rate (65.27±3.18) times/min, systolic blood pressure (105.44±2.17) mmHg, diastolic blood pressure (63.11±3.14) mmHg were significantly lower than the control group (P<0.05);group A patients with triglyceride,total cholesterol,plasma viscosity trimming rate, whole blood viscosity at low shear rate, and whole blood high shear rate were significantly lower than those in group B (P<0.05).ConclusionCompared with clopidogrel, Grillo can effectively improve the blood microcirculation of myocardial ischemia in patients with coronary heart disease, coronary heart disease,relieve myocardial ischemia caused by coronary heart disease The clinical efficacy is remarkable, and it has the value of popularization and Application.

Coronary heart diseasemyocardial ischemiaGrilloclopidogrel

何晓雷、杨丽、孙稳

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北京市延庆区医院(北京大学第三医院延庆医院) 心内科,北京 102100

冠心病 心肌缺血 替格瑞洛 氯吡格雷

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(6)
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