首页|精子形态、精子DNA碎片指数和精浆锌对体外受精-胚胎移植妊娠结局的影响

精子形态、精子DNA碎片指数和精浆锌对体外受精-胚胎移植妊娠结局的影响

扫码查看
目的 探讨精子形态、精子DNA碎片指数和精浆锌对体外受精-胚胎移植妊娠结局的影响.方法 选择2016年1月~2016年6月在韶关市妇幼保健计划生育服务中心辅助生殖中心接受体外受精-胚胎移植助孕治疗的不孕症患者341对,均接受体外受精-胚胎移植.依据妊娠情况比较精子形态,精子DNA碎片指数和精浆锌水平.结果 本次纳入的研究对象为341例,其中妊娠为204例,未妊娠为137例,妊娠率为59.8%(204/341).与妊娠组相比,非妊娠组的正常形态精子百分率较低,畸形精子指数较高(P<0.05),精子DNA碎片指数较高(P<0.05),精浆锌较低(P<0.05),精子形态中的正常形态精子百分率、精子DNA碎片指数和精浆锌与妊娠率均呈线性关系(P<0.05),其中畸形精子指数和精子DNA碎片指数与妊娠结局呈负相关(P<0.05),其余指标呈正相关(P<0.05).结论 精子形态,精子DNA碎片指数和精浆锌均可影响体外受精-胚胎移植妊娠结局,检测精子上述指标可用于预测体外受精-胚胎移植妊娠结局.
Effects of sperm morphology, sperm DNA fragment index and seminal plasma zinc on pregnancy outcome of IVF-ET
Objective To investigate the influence of sperm morphology, sperm DNA fragmentation index and seminal plasma zinc on pregnancy outcome of in vitro fertilization and embryo transfer (IVF-ET).MethodsA total of 341 infertile couples underwent IVF-ET were selected from January 2016 to June 2016 in our hospital.Sperm morphology, sperm DNA fragmentation index and seminal plasma zinc level were compared according to pregnancy.ResultsIn 341 cases, 204 cases pregnancy and 137 cases of no pregnancy, with the pregnancy rate of 59.8%(204/341).Compared with the pregnancy group, the percentage of normal sperm percentage was low, the abnormal sperm index was higher in the non-pregnant group (P<0.05), the sperm DNA index was higher (P<0.05).The percentage of normal sperm, sperm DNA fragmentation index and seminal plasma zinc and pregnancy rate in sperm morphology were linear (P<0.05), And there was a negative correlation between abnormal sperm index and sperm DNA fragment index (P<0.05), and other indicators were positively correlated (P<0.05).ConclusionSperm morphology, sperm DNA fragmentation index and seminal plasma zinc levels may influence the outcome of IVF-ET.The above parameters can be used to predict pregnancy outcome of IVF-ET.

sperm morphologysperm DNA fragmentation indexseminal plasma zincIVF-ETpregnancy outcome

高松城、谢春雨、陈艳、王爱平

展开 >

韶关市妇幼保健计划生育服务中心 生殖医学中心,广东 韶关 512026

精子形态 精子DNA碎片指数 精浆锌 体外受精-胚胎移植 妊娠结局

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(6)
  • 8
  • 9