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胆石症患者胆道感染的病原菌分布与耐药性分析

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目的 探究胆石症患者胆道感染的病原菌分布与耐药性情况,总结临床经验.方法 针对160例胆石症患者进行分析,统计其中出现胆道感染的患者比例,针对患者进行胆汁和静脉血液的收集,检测其病原菌的分布情况,同时针对其耐药性进行分析. 结果 胆石症患者胆道感染发生率为62.5%;胆汁培养阳性率为62.5%,血液检测阳性率为37.5%.革兰阳性菌中包括粪肠球菌、屎肠球菌、葡萄球菌属等,革兰阴性菌则包括大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌等;革兰阳性菌对于庆大霉素和红霉素的耐药性较高,革兰阴性菌则对于氨苄西林和左氧氟沙星的耐药性较高.结论 胆石症患者胆道感染的病原菌分布与耐药性分析发现,其临床的病原菌分布较为广泛,同时病原菌针对不同抗菌药物均呈现出一定的耐药性,因此临床在使用抗菌药物时应该合理选择,以期充分发挥药物效果.
Pathogen distribution and drug resistance of biliary tract infection in patients with cholelithiasis
Objective To investigate the pathogen distribution and drug resistance of biliary tract infection in patients with cholelithiasis, and to summarize the clinical experience.Methods160 patients with cholelithiasis were analyzed.The proportion of patients with biliary tract infection was counted.The bile and venous blood were collected and the distribution of pathogens was detected.The patients were also analyzed for the drug resistance.ResultsThe incidence of biliary tract infection was 62.5%, the positive rate of bile culture was 62.5%, and the positive rate of blood test was 37.5% for 160 patients with cholelithiasis.Gram-positive bacteria include Escherichia coli, Enterococcus faecium, Staphylococcus, Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, etc.;Gram-positive bacteria for the large Methicillin and erythromycin resistance is higher, Gram-negative bacteria for ampicillin and levofloxacin higher resistance.ConclusionThe pathogen distribution and drug resistance of biliary tract infection in patients with cholelithiasis are analyzed.The clinical pathogens are widely distributed.At the same time, the pathogens have different resistance to different antimicrobial agents.Therefore, clinical use should be reasonable choice when using antimicrobial agents, With a view to give full play to drug effects.

cholelithiasisbiliary tract infectionpathogen distributiondrug resistance

尚敏杰、胡智明、张成武、吴伟顶、王知非

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浙江省人民医院 肝胆胰腺外科,浙江 杭州 310014

胆石症 胆道感染 病原菌分布 耐药性

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(6)
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