Study on thermal decomposition mechanism of cobamamide based on TG-DSC analysis
Objective In order to provide the theoretical basis for the stability study of cobamamide, the thermal decomposition mechanism of it has been studied.Methods Based on the qualitative and quantitative analysis of cobamamide samples by X-PRD, IR and HPLC method, TG-DSC analysis of samples with same particle size and other samples with different particle size have been done.Weight loss, peak shape and peak characteristics have been compared, the decomposition of cobamamide thermal mechanism has been obtained and the influencing factors have been discussed.Results The thermal decomposition mechanism of second times dewatering of cobamamide was forward for the first time.The first dewatering occurs at 64 ℃-83 ℃, the second dewatering occurs at around 206 ℃, and complete decomposition occurs at around 276 ℃.Conclusion The results of this study provide important theoretical basis for the development of the quality control of cobamamide.
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万方数据
维普
