生长抑素治疗急性胰腺炎对患者胰腺血流及功能的影响
Analysis on the protective effect of somatostatin on the pancreatic blood flow and function on the patients with acutepancreatitis
杨立安 1冯伟 1张震波1
作者信息
- 1. 陕西省第二人民医院 肝胆外科,陕西 西安 710005
- 折叠
摘要
目的 探讨生长抑素治疗急性胰腺炎对患者胰腺血流及功能的影响.方法 收集陕西省第二人民医院2015年3月～2017年3月收治的急性胰腺炎患者120例,随机分为观察组和对照组,每组均60例.对照组采用基本支持疗法治疗,观察组在其基础上加用生长抑素治疗,持续静滴善宁0.6 mg,后减量至0.3 mg,连续治疗7 d.比较2组患者治疗前后胰腺内外分泌指标、胰腺体部血流指标水平的变化情况和临床疗效,观察其不良反应.结果 观察组的治疗总有效率为96.67%(58/60),对照组的治疗总有效率为80.00%(48/60),观察组治疗总有效率显著高于对照组,比较差异有统计学意义(P＜0.05).治疗前2组胰腺血流量(BF)、血容量(BV)和毛细血管表面通透性(PS)指标水平比较均无统计学差异,治疗后1 d和7 d观察组BF、BV均显著高于对照组,PS水平则显著低于对照组,组间比较差异均有统计学意义(P＜0.05).治疗前2组患者的血清正铜蓝蛋白(CP)、胰岛素(INS)、胰高血糖素(GLU)、血清脂肪酶(LIP)、淀粉酶(AMY)和胰蛋白酶原-2(TPS-2)水平比较差异均无统计学意义,治疗后1 d和7 d观察组患者血清CP、INS均显著高于对照组,GLU、LIP、AMY和TPS-2水平均显著低于对照组,组间比较差异均有统计学意义(P＜0.05).2组均无严重不良反应发生,未见肝肾功能损害.结论 生长抑素治疗急性胰腺炎对患者胰腺血流及其功能均有保护作用,可改善胰腺综合状态,疗效显著.
Abstract
Objective To investigate the effect of somatostatin on pancreatic blood flow and pancreatic function on the patients with acute pancreatitis.Methods 120 patients with acute pancreatitis from March 2015 to March 2017 were collected, and were randomly divided into the observation group and the control group.The control group were given routine treatment, at the basis of this, the observation group were given somatostatin.octreotide 0.6 mg was dripped into intravenous continuously, and was reducted to 0.3 mg, continuous treatment for 7 d.The changes of blood flow and the curative effect of pancreas were compared between the two groups before and after treatment.Results The total effective rate was 96.67%(58/60)in the treatment group and 80.00%(48/60)in the control group.The total effective rate in the observation group was significantly higher than that in the control group, the difference was statistically significant (P<0.05).There was no significant difference in blood flow(BF), blood volume(BV)and capillary surface permeability(PS)between the two groups before treatment.1 and 7 days after treatment, BF, BV in the observation group were higher than those in the control group, the levels of PS were significantly lower than that in the control group, the differences were statistically significant(P<0.05).Before treatment, the differences of(CP), insulin(INS), glucagon(GLU), serum lipase(LIP), amylase(AMY)and trypsinogen-2(TPS)were measured in the two groups were not statistically significant.1 and 7 days after treatment, CP and INS in the observation group were significantly higher than those in the control group, and GLU, LIP, AMY and TPS-2 were significantly lower than those in the control group, the differences between the two groups was statistically significant (P<0.05).Conclusion It has a protective effect on pancreatic blood flow and function which somatostatin was used in the treatment of the patients with acute pancreatitis, it can improve the overall state of pancreas, and has significant therapeutic effect.
关键词
生长抑素/急性胰腺炎/血流/功能Key words
somatostatin/acute pancreatitis/blood flow/function引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据