首页|低分子肝素在老年股骨粗隆间骨折手术前后不同时间点应用的临床观察

低分子肝素在老年股骨粗隆间骨折手术前后不同时间点应用的临床观察

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目的 观察低分子肝素在老年股骨粗隆间骨折手术前后不同时间点应用的临床疗效.方法 抽取160例老年股骨粗隆间骨折患者,其抽取时间为宁波市奉化区人民医院2015年3月~2016年9月期间,依据患者入院先后顺序将其均分为A组、B组、C组以及D组,A组患者在术前48 h采用低分子肝素,B组患者在术前24 h采用低分子肝素,C组患者在术前12 h采用低分子肝素,D组患者在术后12 h采用低分子肝素,分析其临床效果.结果 4组患者出现DVT比例分别为2.5%、15%、15%、37.5%,A组患者和B组、C组以及D组DVT发生率进行对比,差异具有统计学意义(P<0.05).而B组和C组患者DVT发生率进行比对,差异无统计学意义.手术后1个月4组患者进行下肢血管彩超复查,出现新增DVT患者6例,手术后3个月对下肢血管进行彩超复查出现2例新增患者,此外4组患者的出血量数据间经比对差异无统计学意义.结论 老年股骨粗隆间骨折患者在手术前48 h使用低分子肝素能够有效预防DVT的发生,同时不会提升出血性事件发生率,具有较高的安全可靠性.
Clinical observation of low molecular weight heparin in different age points before and after femoral intertrochanteric fracture
Objective To analyze the clinical application of molecular heparin in the treatment of skeletal intertrochanteric fractures at different time points before and after operation.Methods The extraction time of 160 elderly patients with intertrochanteric fractures was divided into group A, group B, group C and group D according to the order of admission in our hospital from March 2015 to September 2016.Patients in group A were treated with molecular heparin at 48 h before surgery.Patients with group B were treated with molecular heparin 24 h before operation.Patients in group C were treated with molecular heparin at 12 h before surgery.Patients in group D were treated with molecular heparin at 12 h postoperatively.Results The incidence of DVT in the four groups was 2.5%, 15%, 15% and 37.5% respectively.The incidence of DVT in group A and group B, group C and group D was statistically significant.The statistical significance was significant(P< 0.05).The incidence of DVT in group B and group C was compared with that in group B.There was no statistically significant difference.1 month after surgery 4 groups of patients with lower extremity vascular color Doppler ultrasound review, there are 6 cases of new DVT patients, 3 months after surgery on the lower extremity vascular color Doppler ultrasound review of 2 cases of new patients, in addition to the four groups of patients with bleeding There was no statistically significant difference between the data.Conclusion The use of molecular heparin in the elderly patients with intertrochanteric fractures for 48 hours can effectively prevent the occurrence of DVT, and will not improve the incidence of hemorrhagic events and have high safety and reliability.

molecular heparinold femoral intertrochanteric fracturesapplication at different time pointsclinical observation

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宁波市奉化区人民医院 药剂科,浙江 宁波 315500

低分子肝素 老年股骨粗隆间骨折 不同时间点应用 临床观察

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(7)
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