他汀类药物联合糖皮质激素治疗原发性肾病综合征的疗效观察
Efficacy of statins combined with glucocorticoid in the treatment of primary nephrotic syndrome
王淑敏 1于杰斌 2郝学喜 2杨彦华1
作者信息
- 1. 山东大学第二医院 医保办,山东 济南 250033
- 2. 山东大学第二医院 急诊科,山东 济南 250033
- 折叠
摘要
目的 研究在原发性肾病综合征疾病中应用他汀类药物联合糖皮质激素方法进行治疗的临床疗效.方法 将2013年5月～2017年2月期间在本院住院治疗的90例原发性肾病综合征患者作为研究对象,应用数字随机法将患者分为对照组与实验组,对照组给予糖皮质激素治疗,实验组的患者在对照组治疗方法的基础上加入他汀类药物治疗,对比分析2组患者治疗后的甘油三酯(TG)、血清总胆固醇(TC)、血CRP、血肌酐、D-二聚体以及24 h尿蛋白量和临床疗效.结果 治疗后,实验组患者的TG、TC、血CRP、血肌酐、D-二聚体以及24 h尿蛋白量等值均显著优于对照组(P＜0.05);实验组患者临床治疗总有效率为95.56%显著高于对照组的73.33%,差异具有统计学意义(P＜0.05).结论 他汀类药物联合糖皮质激素治疗原发性肾病综合征能有效提高患者血清白蛋白,降低尿蛋白含量,促进患者肾功能恢复,临床疗效显著,值得在临床治疗中进行推广应用.
Abstract
Objective To study in primary nephrotic syndrome clinical effect in the treatment of statins combined with glucocorticoid for syndrome disease.Methods From May 2013 to February 2017 treatment of 90 cases of primary nephrotic syndrome patients as the research object, the patients were divided into control group and the application of the experimental group randomly, the control group received glucocorticoid therapy, the experimental group patients in the control group based on the addition of statin therapy, compared two groups of patients after treatment of triglyceride (TG), serum total cholesterol (TC), serum CRP, serum creatinine, two D dimer And 24 h urinary protein and clinical curative effect.Results After the treatment, the patients in the experimental group TG, TC, blood CRP, serum creatinine, two D dimer and 24 h urinary protein equivalents were significantly better than the control group (P<0.05);the clinical treatment of patients in the experimental group the total efficiency of 95.56% was significantly higher than that of the control group (73.33%), the difference was statistically significant(P<0.05).Conclusion Statins combined with glucocorticoids in the treatment of primary nephrotic syndrome can effectively improve serum albumin, reduce urinary protein content, promote the recovery of renal function, clinical curative effect, worth in clinical treatment.Line promotion application.
关键词
原发性肾病综合征/糖皮质激素/他汀类药物/肾功能/临床疗效Key words
primary nephrotic syndrome/glucocorticoids/statins/renal function/clinical efficacy引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据