Effects of somatostatin combined with early enteral nutrition on inflammatory factors and intestinal permeability in patients with severe acute pancreatitis
Objective To investigate the effects of somatostatin combined with early enteral nutrition on inflammatory factors and intestinal permeability in patients with severe acute pancreatitis (SAP).Methods 70 patients with severe acute pancreatitis were randomly divided into the control group (35 cases) and the observation group (35 cases).The control group were given double somatostatin, the observation group were received double somatostatin combined with early enteral nutrition support.Before and after treatment in the two gorups, TNF-a and IL-1 levels were measured by ELISA;intestinal permeability index was indirect calculated by high performance liquid chromatography.Clinical curative effect and inflammatory factors and intestinal permeability were compared in the two groups.Results Seven days after treatment, the secondary infection rate, operation rate and mortality in the observation were lower than those in the control group (P<0.05);before treatment, TNF-a and IL-1 level in the two groups had no significant difference;Seven days after treatment, TNF-a and IL-1 in the observation group were lower than those in the control group (P<0.05);seven days after treatment,blood lactate levels in the observation group was higher than that in the control group and diamineoxidase was lower than that in the control group (P<0.05).Conclusion Double somatostatin combined with early enteral nutrition support can improve inflammatory factors and intestinal permeability in patients with severe acute pancreatitis, and is worthy of popularization and application.
severe acute pancreatitissomatostatinenteral nutritioninflammatory factorintestinal permeability
NETL
NSTL
万方数据
维普
