首页|菊明降压丸联合苯磺酸氨氯地平治疗原发性高血压的临床研究

菊明降压丸联合苯磺酸氨氯地平治疗原发性高血压的临床研究

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目的 分析菊明降压丸联合苯磺酸氨氯地平治疗原发性高血压的临床疗效.方法 将本院心内科2015年8月~2016年10月收治的原发性高血压患者126例进行分组治疗,各63例.对照组给予苯磺酸氨氯地平治疗,观察组联合菊明降压丸治疗,分析2组降压疗效和对相关因子的影响以及安全性.结果 ①观察组的总有效率为95.24%,高于对照组80.95%(P<0.05).②治疗后观察组收缩压(SBP)和舒张压(DBP)[分别为(128.5±6.3)、(78.4±5.2)mmHg]均低于对照组[(140.2±7.5)、(88.7±5.5)mmHg](均P<0.05).③治疗后,观察组血浆一氧化氮(NO)和血清内皮素(ET)[分别为(70.16±5.51)μmol/L、(66.24±5.40)ng/L],均优于对照组[(64.16±5.33)μmol/L、(73.05±5.68)ng/L](均P<0.05).④对照组出现11.11%的不良反应,高于观察组4.76%,但组间差异无统计学意义.结论 菊明降压丸联合苯磺酸氨氯地平对于原发性高血压患者有更佳的疗效,且用药安全.
Clinical effects of Juming Jiangya pill combined with amlodipine besylate in treatment of essential hypertension
Objective To analyse clinical effects of Juming Jiangya pill combined with amlodipine besylate in treatment of essential hypertension.Methods 126 patients with essential hypertension from August 2015 to October 2016 were grouped two groups and each with 63 cases.The control group were treated with amlodipine besylate,and observation group was treated with Juming Jiangya pill.The effect of 2 groups of antihypertensive treatment, the influence on related factors and the safety were analyzed.Results (After treatment,total effective rate of observation group was 95.24%,higher than that of control group 80.95%(P<0.05).(After treatment,SBP and DBP level of observation group[were(128.5±6.3),(78.4±5.2)mmHg],lower than that of control group[(140.2±7.5),(88.7±5.5)mmHg](all P<0.05).③After treatment,plasma NO and serum ET level of observation group were[(70.16±5.51)μmol/L,(66.24±5.40)ng/L],better than that of control group[(64.16±5.33)μmol/L,(73.05±5.68)ng/L)](all P<0.05).④During treatment,proportion of adverse reactions of control group was 11.11%,higher than that of observation group 4.76%,difference was not statistically significant.Conclusion Juming Jiangya pill combined with amlodipine besylate have better curative effect and medication safety.

Juming Jiangya pillamlodipine besylateessential hypertension

张静、田晓玲、许保海

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北京积水潭医院 中药房,北京 100035

北京中医药大学东方医院 药学部,北京 100078

菊明降压丸 苯磺酸氨氯地平 原发性高血压

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(7)
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