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瑞芬太尼复合七氟醚或异丙酚在颅内肿瘤患者手术麻醉中的应用比较

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目的 研究分析瑞芬太尼复合七氟烷或异丙酚在颅内肿瘤患者手术麻醉中的应用比较.方法 选取嘉兴市中医医院2016年1月~2016年12月收治的60例进行颅内肿瘤手术患者作为本次研究过程中的研究对象,随机分为A组和B组,每组30例.A组患者利用瑞芬太尼复合七氟烷麻醉,B组患者进行瑞芬太尼复合异丙酚麻醉.比较分析A组与B组患者相关临床指标.结果 在手术过程中,2组患者呼气末二氧化碳分压以及脉搏血氧饱和度均变化评分.2组患者在插管即刻的心率以及无创血压均显著低于未进行麻醉前,A组降低的程度更大,差异有统计学意义(P<0.05).A组进行麻醉后30 min以及1 h的颈内静脉氧饱和度显著高于B组,脑动静脉血氧分压低于B组,差异有统计学意义(P<0.05).A组患者的麻醉时间为(187.3±22.7)min,清醒拔管时间为(22.1±8.2)min.B组患者的麻醉时间为(181.4±19.1)min,清醒拔管时间为(10.2±5.3)min.由此可得,B组患者麻醉时间以及清醒拔管时间均显著少于A组,差异有统计学意义(P<0.05).结论 瑞芬太尼复合异丙酚与七氟醚在颅内肿瘤患者手术麻醉中相比,两种方法均可有效稳定患者的相关生命体征,但瑞芬太尼复合异丙酚苏醒时间较快,在一定程度上有助于脑氧供需平衡,具有临床进一步推广和应用的意义.
Comparison of remifentanil combined with sevoflurane or propofol in anesthesia for patients with intracranial tumors
Objective To study the application of remifentanil combined with sevoflurane or propofol in the anesthesia of patients with intracranial tumors.Methods From January 2015 to December 2015,60 patients with intracranial tumor surgery in our hospital were selected as the research object in this study.They were randomly divided into A group and B group,each group had a total of 30 cases.Patients in group A were treated with remifentanil combined with sevoflurane anesthesia,and B group was treated with remifentanil and propofol anesthesia.Comparative analysis of A group and B group of patients with clinical indicators.Results During the operation,two groups of patients with end tidal carbon dioxide partial pressure and pulse oxygen saturation score.Two groups of patients in the immediate intubation heart rate and blood pressure were significantly lower than before anesthesia,A group reduced the degree of greater,with statistical difference(P<0.05).In group A,30 min and 1H were significantly higher than those in group B after anesthesia,and the difference was statistically significant(P<0.05).The anesthesia time of A group was(187.3±22.7)min,and the extubation time was(22.1±8.2)min.The anesthesia time of B group was(181.4±19.1)min,and the extubation time was(10.2±5.3)min.As a result,B group of patients with anesthesia time and extubation time were significantly less than the A group,and with statistical difference(P<0.05).Conclusion Remifentanil Combined with propofol and sevoflurane anesthesia in patients with intracranial tumors compared to two kinds of methods can effectively stabilize the patient's life signs,but remifentanil and propofol recovery time is fast,contribute to the balance of cerebral oxygen supply and consumption in a certain extent,with the further promotion and application of clinical significance.

reventa nisevofluranepropofolintracranial tumorsurgical anesthesia

盖赵辉、杨亦斌、王海燕、张云红、张艳丽、李博

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嘉兴市中医医院麻醉科,浙江 嘉兴 314001

瑞芬太尼 七氟醚 异丙酚 颅内肿瘤 手术麻醉

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(7)
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