目的 探究盐酸氨溴索与布地奈德联合治疗小儿支气管肺炎对患者C-反应蛋白、WBC水平的影响.方法 选取宁波市第四医院儿科2013年5月～2016年12月收治的支气管肺炎患者100例,按照随机数字表法将其均分为观察组和对照组,每组50例.对照组给与常规治疗,观察组在对照组基础上给予盐酸氨溴索与布地奈德联合治疗,疗程为14 d.在治疗前及治疗后14 d对患者进行C-反应蛋白、WBC水平测定,观察并统计测定结果.结果 2组患者CRP含量组间、多时间点比较差异均有统计学意义(F=11.50,P=0.003;F=4.78,P=0.03;F=5.45,P=0.02).观察组患者治疗后14 d CRP含量明显低于对照组(t=14.12,P＜0.05),差异具有统计学意义.2组患者WBC计数组间、多时间点比较差异均有统计学意义(F=11.52,P=0.003;F=4.73,P=0.03;F=5.44,P=0.02).且观察组患者治疗后14 d WBC计数明显低于对照组(t=8.12,P＜0.05),差异具有统计学意义.对照组患者治愈、显效、无效分别为20、13、15例,观察组分别为30、15、5例.经秩和检验2组患者有效率差异有统计学意义(u=2.33,P＜0.05).观察组总有效率为90.0%,明显高于对照组70.0%,差异有统计学意义(x2=6.25,P＜0.05).结论 盐酸氨溴索与布地奈德联合治疗小儿支气管肺炎,疗效确切,能有效降低患者CRP以及WBC计数,值得在临床广泛推广.
Effect of ambroxol hydrochloride combined with budesonide in treatment of children bronchial pneumonia on C-reactive protein level in patients with C-, WBC
Objective To explore and analyze the effect of ambroxol hydrochloride combined with budesonide in treatment of children bronchial pneumonia on C-reactive protein level and WBC levels.Methods 100 cases of patients with bronchial pneumonia treated in our hospital from May 2015 to December 2016, were randomly divided into observation group and control group, 50 cases in each group.The control group were given routine treatment, while the observation group were given ambroxol hydrochloride combined with budesonide treatment on the basis of the control group,the course of treatment was 14 days.C-reactive protein and WBC levels were measured before treatment and 14 days after treatment, the Results were observed and statistical.ResultsThere were significant differences in the content of CRP between groups and multiple time points(F=11.50, P=0.003;F=4.78, P=0.03;F=5.45, P=0.02).The content of CRP 14 days after treatment in the observation group were significantly lower than the control group(t=14.12,P<0.05), the difference was statistically significant.There were significant differences in the WBC counts between groups and multiple time points(F=11.52, P=0.003;F=4.73, P=0.03;F=5.44, P=0.02),the difference was statistically significant.The count of WBC 14 days after treatment in the observation group after treatment were significantly lower than the control group(t=8.12, P<0.05), the difference was statistically significant.The number of cured, effective and ineffective cases in the control group was 20, 13 and 15, respectively.The observation group was 30, 15, and 5 cases, respectively.By rank sum test, the difference of the effective rate between the 2 groups was statistically significant(u=2.33, P<0.05).And the total effective rate in observation group was 90.0%, which was significantly higher than the control group(70.0%)(x2=6.25, P<0.05), the difference was statistically significant.Conclusion Ambroxol hydrochloride combined with budesonide in the treatment of bronchial pneumonia in children is effective and can effectively reduce the CRP and WBC count, so it is worth popularizing widely in clinic.
ambroxol hydrochloridebudesonidebronchopneumoniaC-reactive protein and WBC levels
NETL
NSTL
万方数据
维普
