关于氨磺必利郁抗抑作用的研究
Research on the power of tolbutamide will benefit the antidepressant
范思海 1苏艳南 1原红莲1
作者信息
- 1. 山西省精神卫生中心 临床心理科,山西 太原 030045
- 折叠
摘要
目的 探讨小剂量氨磺必利抗抑郁治疗的疗效及安全性.方法 选取120例首发抑郁患者,随机分为氨磺必利组、艾司西酞普组与合用药组,各40例.分别给予氨磺必利片0.2/d,艾司西酞普兰片20 mg/d,艾司西酞普兰片20 mg/d+氨磺必利片0.2/d治疗.于治疗前及治疗 1、2、4、8周末用汉密顿抑郁量表(HAMD)评定临床疗效、副反应量表(TESS)评定药物不良反应.结果 3组在治疗第8 周末HAMD评分均较治疗前均有明显改善(P＜0.01);1和2周末的评分,合用药组与单用药组评分比较差异有统计学意义(P值均＜0.01),而单用药组间比较差异无统计学意义,4周末评分,3组组间比较均差异有统计学意义(均P＜0.05),8周末评分,合用药组与艾司西酞普组比较差异无统计学意义,但氨磺必利组与另外2组比较均差异有统计学意义(均P＜0.01).结论 小剂量的氨磺必利片有抗抑郁作用,但远期疗效不如治疗量的艾司西酞普兰,而艾司西酞普兰合用小剂量氨磺必利可以明显加快抗抑郁治疗起效.
Abstract
Objective To investigate the efficacy and safety of low-dose ammonia sulfur-sulfur-resistant treatment.Methods 120 patients with initial depression were randomly divided into a group(40 cases), the estercalyptrin group(40)and the drug group(40).The treatment was treated by the treatment of the ammonia sulfonate, 20 mg/d, 20 mg/d, and 20 mg/d of escitaloplan tablet.The clinical efficacy and response scale(TESS)was evaluated with the Hamilton depression scale(TESS)in the treatment of 1, 2, 4 and 8 over the weekend.Results Three groups showed significant improvement(P<0.01)during the 8th weekend of treatment of the HAMD scores.Grade 1 and 2 weekend, combined treatment group compared with single drug group score had significant difference(P<0.01), and the contrast between the single drug groups had no significant difference, 4 score over the weekend, and comparison between the three way were significant differences(P<0.05), 8 scores over the weekend, and share with escitalopram phthalein general group is no difference, but tolbutamide will benefit group compared with the other two groups had significant difference(P<0.01).Conclusion Small doses of tolbutamide will benefit has antidepressant effect, but the long-term curative effect of treatment is better than the amount of escitalopram citalopram, and share small doses of escitalopram citalopram tolbutamide will benefit can obviously accelerate the antidepressant treatment work.
关键词
氨磺必利/艾司西酞普兰片/抑郁发作Key words
ammonia sulfide/escitalopram tablet/depressive episode引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据