瑞舒伐他汀钙联合氯吡格雷与阿司匹林预防老年短暂性脑缺血发作患者脑梗死的效果及对血脂、血小板的影响
Effect of rosuvastatin calcium combined with clopidogrel and aspirin on prevention of cerebral infarction in elderly patients with transient ischemic attack and the effects on blood lipids and platelets
潘文良 1陶琴芳2
作者信息
- 1. 海盐县人民医院 神经内科,浙江 海盐 314300
- 2. 海盐县人民医院 肿瘤内科,浙江 海盐 314300
- 折叠
摘要
目的 研究瑞舒伐他汀钙联合氯吡格雷与阿司匹林预防老年短暂性脑缺血发作患者脑梗死的效果,以及对血脂、血小板的影响.方法 选取2014年9月～2017年5月到海盐县人民医院接受治疗的80例老年TIA患者.将所有患者随机分为观察组和对照组各40例.对照组患者采用氯吡格雷与阿司匹林治疗方案,观察组患者采用瑞舒伐他汀钙联合氯吡格雷与阿司匹林治疗方案.对比2组患者的脑梗死预防效果、血脂和血小板变化情况.结果 观察组脑梗死发生率5.00%,不良反应发生率10.00%,明显低于对照组患者的(22.5%,17.5%),2组差异具有统计学意义(P＜0.05).对比2组患者血脂水平,治疗后,观察组各项指标TC(4.89±1.13)mmol/L、TG(1.04±1.02)mmol/L、LDL-C(2.62±1.22)mmol/L明显低于对照组(5.57±1.20)mmol/L、(1.58±1.06)mmol/L、(3.39±1.24)mmol/L,具有统计学意义(P＜0.05).治疗后观察组PT(16.88±1.97)、APTT(46.23±4.22)均长于对照组(14.01±2.02,38.21±3.99),PLT(150.44±9.87)低于对照组(165.82±9.71),差异具有统计学意义(P＜0.05).结论 瑞舒伐他汀钙联合氯吡格雷与阿司匹林对预防老年短暂性脑缺血发作患者脑梗死具有显著的效果,同时能够降低患者血脂水平,延长PT、APTT,降低PLT,具有较高的临床应用价值.
Abstract
Objective To study the effect of rosuvastatin calcium combined with clopidogrel and aspirin on preventing cerebral infarction in elderly patients with transient ischemic attack, and the influence on blood lipid and platelet.Methods 80 elderly patients with TIA were treated in Haiyan people's hospital from September 2014 to May 2017.All the patients were randomly divided into the observation group and the control group with 40 cases in each group.The control group were treated with clopidogrel and aspirin, and the observation group was treated with rosuvastatin calcium combined with clopidogrel and aspirin.The effect of cerebral infarction prevention, blood lipid and platelet change were compared between the two groups.Results Cerebral infarction incidence was 5% in the observation group, the incidence of adverse reactions was 10%, which were significantly lower than 22.5% and 17.5% in the control group, the differences were statistically significant (P<0.05).Compared two groups of patients with blood lipid levels after the treatment, the indicators of the observation groupTC (4.89±1.13) mmol/L、TG (1.04±1.02) mmol/L、LDL-C (2.62±1.22) mmol/L was significantly lower than the control group (5.57±1.20) mmol/L、(1.58±1.06) mmol/L、(3.39±1.24) mmol/L, with statistical significance (P<0.05).After treatment, PT (16.88±1.97), APTT (46.23±4.22) in the observation group were longer than (14.01±2.02) (38.21±3.99) in the control group, PLT (150.44±9.87) in the observation group is lower (165.82±9.71) in the control group, the differences were statistically significant (P<0.05).Conclusion Rosuvastatin calcium combined with clopidogrel and aspirin has a significant effect on the prevention of elderly patients with transient ischemic attack of cerebral infarction, which can reduce the blood lipid level, prolong PT, reduce PLT, APTT, and has high value in clinical application.
关键词
短暂性脑缺血发作/瑞舒伐他汀钙/氯吡格雷/阿司匹林Key words
transient ischemic attack/rosuvastatin calcium/clopidogrel/aspirin引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据